Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa

Erik Schaftenaar; Christina Meenken; G Seerp Baarsma; N Sellina Khosa; Ad Luijendijk; James A McIntyre; Albert D M E Osterhaus; Georges M G M Verjans; Remco P H Peters

doi:10.1136/bjophthalmol-2016-308645

Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa

Erik Schaftenaar, Christina Meenken, G Seerp Baarsma, N Sellina Khosa, Ad Luijendijk, James A McIntyre, Albert D M E Osterhaus, Georges M G M Verjans, Remco P H Peters

Medical retina and Uveitis

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › Onderzoek › peer review

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AIMS: To determine the burden of disease in a unique sample of patients with uveitis from a rural South African setting.

METHODS: Data in this cross-sectional study were collected from patients presenting with uveitis (n=103) at the ophthalmology outpatient department of three hospitals in rural South Africa. Demographic and clinical data were collected, and laboratory analysis of aqueous humour, serological evaluation and routine diagnostics for tuberculosis (TB) were performed.

RESULTS: Sixty-six (64%) participants were HIV infected. Uveitis was predominantly of infectious origin (72%) followed by idiopathic (16%) and autoimmune (12%). Infectious uveitis was attributed to herpes virus (51%), Mycobacterium tuberculosis (24%) and Treponema pallidum (7%) infection. HIV-infected individuals were more likely to have infectious aetiology of uveitis compared with HIV-uninfected individuals (83% vs 51%; p=0.001).

CONCLUSIONS: Microbial aetiology of uveitis is common in areas where HIV and TB are endemic. In these settings, a high index of suspicion for infectious origin of uveitis is warranted.

Originele taal-2	Engels
Pagina's (van-tot)	1312-6
Aantal pagina's	5
Tijdschrift	British Journal of Ophthalmology
Volume	100
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1136/bjophthalmol-2016-308645
Status	Gepubliceerd - okt. 2016

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10.1136/bjophthalmol-2016-308645

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Schaftenaar, E., Meenken, C., Baarsma, G. S., Khosa, N. S., Luijendijk, A., McIntyre, J. A., Osterhaus, A. D. M. E., Verjans, G. M. G. M., & Peters, R. P. H. (2016). Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa. British Journal of Ophthalmology, 100(10), 1312-6. https://doi.org/10.1136/bjophthalmol-2016-308645

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title = "Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa",

abstract = "AIMS: To determine the burden of disease in a unique sample of patients with uveitis from a rural South African setting.METHODS: Data in this cross-sectional study were collected from patients presenting with uveitis (n=103) at the ophthalmology outpatient department of three hospitals in rural South Africa. Demographic and clinical data were collected, and laboratory analysis of aqueous humour, serological evaluation and routine diagnostics for tuberculosis (TB) were performed.RESULTS: Sixty-six (64%) participants were HIV infected. Uveitis was predominantly of infectious origin (72%) followed by idiopathic (16%) and autoimmune (12%). Infectious uveitis was attributed to herpes virus (51%), Mycobacterium tuberculosis (24%) and Treponema pallidum (7%) infection. HIV-infected individuals were more likely to have infectious aetiology of uveitis compared with HIV-uninfected individuals (83% vs 51%; p=0.001).CONCLUSIONS: Microbial aetiology of uveitis is common in areas where HIV and TB are endemic. In these settings, a high index of suspicion for infectious origin of uveitis is warranted.",

keywords = "Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Eye Infections, Bacterial/epidemiology, Eye Infections, Viral, Female, HIV, HIV Infections/epidemiology, Humans, Male, Middle Aged, Prevalence, Retrospective Studies, Rural Population, South Africa/epidemiology, Tuberculosis/epidemiology, Uveitis/epidemiology, Young Adult",

author = "Erik Schaftenaar and Christina Meenken and Baarsma, {G Seerp} and Khosa, {N Sellina} and Ad Luijendijk and McIntyre, {James A} and Osterhaus, {Albert D M E} and Verjans, {Georges M G M} and Peters, {Remco P H}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",

year = "2016",

month = oct,

doi = "10.1136/bjophthalmol-2016-308645",

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T1 - Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa

AU - Schaftenaar, Erik

AU - Meenken, Christina

AU - Baarsma, G Seerp

AU - Khosa, N Sellina

AU - Luijendijk, Ad

AU - McIntyre, James A

AU - Osterhaus, Albert D M E

AU - Verjans, Georges M G M

AU - Peters, Remco P H

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PY - 2016/10

Y1 - 2016/10

N2 - AIMS: To determine the burden of disease in a unique sample of patients with uveitis from a rural South African setting.METHODS: Data in this cross-sectional study were collected from patients presenting with uveitis (n=103) at the ophthalmology outpatient department of three hospitals in rural South Africa. Demographic and clinical data were collected, and laboratory analysis of aqueous humour, serological evaluation and routine diagnostics for tuberculosis (TB) were performed.RESULTS: Sixty-six (64%) participants were HIV infected. Uveitis was predominantly of infectious origin (72%) followed by idiopathic (16%) and autoimmune (12%). Infectious uveitis was attributed to herpes virus (51%), Mycobacterium tuberculosis (24%) and Treponema pallidum (7%) infection. HIV-infected individuals were more likely to have infectious aetiology of uveitis compared with HIV-uninfected individuals (83% vs 51%; p=0.001).CONCLUSIONS: Microbial aetiology of uveitis is common in areas where HIV and TB are endemic. In these settings, a high index of suspicion for infectious origin of uveitis is warranted.

AB - AIMS: To determine the burden of disease in a unique sample of patients with uveitis from a rural South African setting.METHODS: Data in this cross-sectional study were collected from patients presenting with uveitis (n=103) at the ophthalmology outpatient department of three hospitals in rural South Africa. Demographic and clinical data were collected, and laboratory analysis of aqueous humour, serological evaluation and routine diagnostics for tuberculosis (TB) were performed.RESULTS: Sixty-six (64%) participants were HIV infected. Uveitis was predominantly of infectious origin (72%) followed by idiopathic (16%) and autoimmune (12%). Infectious uveitis was attributed to herpes virus (51%), Mycobacterium tuberculosis (24%) and Treponema pallidum (7%) infection. HIV-infected individuals were more likely to have infectious aetiology of uveitis compared with HIV-uninfected individuals (83% vs 51%; p=0.001).CONCLUSIONS: Microbial aetiology of uveitis is common in areas where HIV and TB are endemic. In these settings, a high index of suspicion for infectious origin of uveitis is warranted.

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KW - Aged

KW - Aged, 80 and over

KW - Cross-Sectional Studies

KW - Eye Infections, Bacterial/epidemiology

KW - Eye Infections, Viral

KW - Female

KW - HIV

KW - HIV Infections/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Retrospective Studies

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KW - South Africa/epidemiology

KW - Tuberculosis/epidemiology

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KW - Young Adult

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DO - 10.1136/bjophthalmol-2016-308645

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JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 10

ER -

Uveitis is predominantly of infectious origin in a high HIV and TB prevalence setting in rural South Africa

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