TY - JOUR
T1 - Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma
AU - Ugahary, Luana Cahya
AU - Ganteris, Elisabeth
AU - Veckeneer, Marc
AU - Cohen, Adam C
AU - Jansen, Jan
AU - Mulder, Paul G H
AU - van Meurs, Jan C
PY - 2006/3
Y1 - 2006/3
N2 - PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.
AB - PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.
KW - Administration, Topical
KW - Adult
KW - Aged
KW - Chronic Disease
KW - Cross-Over Studies
KW - Deoxyepinephrine/administration & dosage
KW - Dopamine Agonists/administration & dosage
KW - Double-Blind Method
KW - Eye Injuries, Penetrating/complications
KW - Female
KW - Humans
KW - Intraocular Pressure/drug effects
KW - Male
KW - Middle Aged
KW - Ocular Hypotension/drug therapy
KW - Prospective Studies
KW - Tonometry, Ocular
KW - Uveitis/complications
KW - Visual Acuity
KW - Vitrectomy/adverse effects
U2 - 10.1016/j.ajo.2005.09.034
DO - 10.1016/j.ajo.2005.09.034
M3 - Article
C2 - 16490513
SN - 0002-9394
VL - 141
SP - 571
EP - 573
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -