The tarsal plate manifestation of IgG4-related disease

J S N Verhoekx, A F Karim, J A M van Laar, R M Verdijk, D Paridaens

Onderzoeksoutput: Bijdrage aan tijdschriftBriefpeer review

Samenvatting

PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.

METHOD: Interventional case report.

RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.

CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

Originele taal-2Engels
Pagina's (van-tot)1613-1615
Aantal pagina's3
TijdschriftInternational Ophthalmology
Volume39
Nummer van het tijdschrift7
DOI's
StatusGepubliceerd - jul 2019

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