The tarsal plate manifestation of IgG4-related disease

J S N Verhoekx; A F Karim; J A M van Laar; R M Verdijk; D Paridaens

doi:10.1007/s10792-018-0974-3

The tarsal plate manifestation of IgG4-related disease

J S N Verhoekx, A F Karim, J A M van Laar, R M Verdijk, D Paridaens

Orbita and oculoplastic surgery

Onderzoeksoutput: Bijdrage aan tijdschrift › Brief › peer review

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PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.

METHOD: Interventional case report.

RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.

CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

Originele taal-2	Engels
Pagina's (van-tot)	1613-1615
Aantal pagina's	3
Tijdschrift	International Ophthalmology
Volume	39
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1007/s10792-018-0974-3
Status	Gepubliceerd - jul. 2019

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10.1007/s10792-018-0974-3

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title = "The tarsal plate manifestation of IgG4-related disease",

abstract = "PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.METHOD: Interventional case report.RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.",

keywords = "Administration, Topical, Biopsy, Eyelids/pathology, Female, Glucocorticoids/administration & dosage, Humans, Immunoglobulin G4-Related Disease/complications, Middle Aged, Neurocutaneous Syndromes/diagnosis, Pigmentation Disorders/diagnosis",

author = "Verhoekx, {J S N} and Karim, {A F} and {van Laar}, {J A M} and Verdijk, {R M} and D Paridaens",

year = "2019",

month = jul,

doi = "10.1007/s10792-018-0974-3",

language = "English",

volume = "39",

pages = "1613--1615",

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TY - JOUR

T1 - The tarsal plate manifestation of IgG4-related disease

AU - Verhoekx, J S N

AU - Karim, A F

AU - van Laar, J A M

AU - Verdijk, R M

AU - Paridaens, D

PY - 2019/7

Y1 - 2019/7

N2 - PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.METHOD: Interventional case report.RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

AB - PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.METHOD: Interventional case report.RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.

KW - Administration, Topical

KW - Biopsy

KW - Eyelids/pathology

KW - Female

KW - Glucocorticoids/administration & dosage

KW - Humans

KW - Immunoglobulin G4-Related Disease/complications

KW - Middle Aged

KW - Neurocutaneous Syndromes/diagnosis

KW - Pigmentation Disorders/diagnosis

U2 - 10.1007/s10792-018-0974-3

DO - 10.1007/s10792-018-0974-3

M3 - Letter

C2 - 29926366

SN - 1573-2630

VL - 39

SP - 1613

EP - 1615

JO - International Ophthalmology

JF - International Ophthalmology

IS - 7

ER -

The tarsal plate manifestation of IgG4-related disease

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