TY - JOUR
T1 - Retinal vasculitis occurring with common variable immunodeficiency syndrome
AU - van Meurs, J C
AU - Lightman, S
AU - de Waard, P W
AU - Baarsma, G S
AU - van Suijlekom-Smit, L W
AU - van de Merwe, J P
AU - de Groot, R
PY - 2000/2
Y1 - 2000/2
N2 - PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.
AB - PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.
KW - Capillary Permeability
KW - Child
KW - Child, Preschool
KW - Common Variable Immunodeficiency/complications
KW - Cyclosporine/therapeutic use
KW - Female
KW - Glucocorticoids/therapeutic use
KW - Humans
KW - Macular Edema/drug therapy
KW - Male
KW - Retinal Diseases/drug therapy
KW - Retinal Neovascularization/drug therapy
KW - Retinal Vessels/pathology
KW - Syndrome
KW - Vasculitis/drug therapy
KW - Vision Disorders/etiology
KW - Visual Acuity
U2 - 10.1016/s0002-9394(99)00325-6
DO - 10.1016/s0002-9394(99)00325-6
M3 - Letter
C2 - 10682991
SN - 0002-9394
VL - 129
SP - 269
EP - 270
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 2
ER -