Samenvatting
PURPOSE: To determine the relation of orbital xanthogranuloma with IgG4-related disease.
METHODS: Retrospective consecutive case series over a period of 25 years. We searched our charts for histologically confirmed orbital xanthogranuloma. Patient files were reviewed for clinical and follow up data including presence or absence of systemic non-ophthalmic manifestations of IgG4 related disease. Slides were re-examined and histopathological classification was re-assessed. Sixteen cases of orbital xanthogranuloma were evaluated. Immunohistochemical stains for IgG and IgG4 were performed. Positive immunohistochemical staining required increased IgG4-positive plasma cells in the involved tissues scored as >50 per high-power field, with IgG4/IgG ratio >0.40.
RESULTS: According to the criteria described above 8/16 (50%) cases showed increased numbers of IgG4-positive plasma cells in the specimens. Two of these patients may have had signs of systemic disease.
CONCLUSION: Raised numbers of IgG4-positive plasma cells are a common finding in histopathological specimens of xanthogranulomatous disease of the orbit and are often not indicative for IgG4 related systemic disease.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 17-22 |
Aantal pagina's | 6 |
Tijdschrift | Orbit (Amsterdam, Netherlands) |
Volume | 33 |
Nummer van het tijdschrift | 1 |
DOI's | |
Status | Gepubliceerd - feb. 2014 |