Orbital chondrosarcoma developing in a patient with Paget disease

C M Mooy; N C Naus; A de Klein; W A van den Bosch; D A Paridaens

doi:10.1016/s0002-9394(98)00405-x

Orbital chondrosarcoma developing in a patient with Paget disease

C M Mooy, N C Naus, A de Klein, W A van den Bosch, D A Paridaens

Orbita and oculoplastic surgery

Onderzoeksoutput: Bijdrage aan tijdschrift › Brief › peer review

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PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease.

METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed.

RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization.

CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.

Originele taal-2	Engels
Pagina's (van-tot)	619-21
Aantal pagina's	3
Tijdschrift	American Journal of Ophthalmology
Volume	127
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1016/s0002-9394(98)00405-x
Status	Gepubliceerd - mei 1999

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10.1016/s0002-9394(98)00405-x

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@article{6691b768e6d245df972ac89dc3496320,

title = "Orbital chondrosarcoma developing in a patient with Paget disease",

abstract = "PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease.METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed.RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization.CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.",

keywords = "Chondrosarcoma/diagnostic imaging, DNA, Neoplasm/analysis, Female, Frontal Bone/pathology, Humans, In Situ Hybridization, Fluorescence, Middle Aged, Orbital Neoplasms/diagnostic imaging, Osteitis Deformans/complications, Temporal Bone/pathology, Tomography, X-Ray Computed",

author = "Mooy, \{C M\} and Naus, \{N C\} and \{de Klein\}, A and \{van den Bosch\}, \{W A\} and Paridaens, \{D A\}",

year = "1999",

month = may,

doi = "10.1016/s0002-9394(98)00405-x",

language = "English",

volume = "127",

pages = "619--21",

number = "5",

}

TY - JOUR

T1 - Orbital chondrosarcoma developing in a patient with Paget disease

AU - Mooy, C M

AU - Naus, N C

AU - de Klein, A

AU - van den Bosch, W A

AU - Paridaens, D A

PY - 1999/5

Y1 - 1999/5

N2 - PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease.METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed.RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization.CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.

AB - PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease.METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed.RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization.CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.

KW - Chondrosarcoma/diagnostic imaging

KW - DNA, Neoplasm/analysis

KW - Female

KW - Frontal Bone/pathology

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Middle Aged

KW - Orbital Neoplasms/diagnostic imaging

KW - Osteitis Deformans/complications

KW - Temporal Bone/pathology

KW - Tomography, X-Ray Computed

U2 - 10.1016/s0002-9394(98)00405-x

DO - 10.1016/s0002-9394(98)00405-x

M3 - Letter

C2 - 10334366

SN - 0002-9394

VL - 127

SP - 619

EP - 621

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 5

ER -

Orbital chondrosarcoma developing in a patient with Paget disease

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