TY - JOUR
T1 - Miotics after modern cataract surgery are history
AU - Dieleman, Myrthe
AU - Wubbels, René J
AU - De Waard, Peter W T
PY - 2012/4
Y1 - 2012/4
N2 - PURPOSE: The aim of this study was to investigate the usefulness of a long-acting miotic (physostigmine) after phacoemulsification in preventing peripheral anterior synechiae (PAS), lens dislocation, and high postoperative intraocular pressure.METHODS: This was a prospective randomized controlled trial of 400 patients (400 eyes) scheduled for phacoemulsification. Patients were randomly assigned either to receive a single application of physostigmine ointment directly after phacoemulsification or not. The main outcome measures were the change of intraocular pressure (IOP) before and after surgery, number of extra outpatient clinic visits within 4 weeks postoperatively, verbal rating pain scale (VRS), status of the angle by gonioscopy, and best corrected visual acuity (BCVA).RESULTS: There was no significant difference in IOP and BCVA between both groups. There were more patients who reported a VRS score of more than 3 in the physostigmine group (P=0.021). PAS or (anterior) lens dislocation was not observed.CONCLUSION: In eyes without co-morbidity, the routine use of physostigmine ointment has lost its rationale.
AB - PURPOSE: The aim of this study was to investigate the usefulness of a long-acting miotic (physostigmine) after phacoemulsification in preventing peripheral anterior synechiae (PAS), lens dislocation, and high postoperative intraocular pressure.METHODS: This was a prospective randomized controlled trial of 400 patients (400 eyes) scheduled for phacoemulsification. Patients were randomly assigned either to receive a single application of physostigmine ointment directly after phacoemulsification or not. The main outcome measures were the change of intraocular pressure (IOP) before and after surgery, number of extra outpatient clinic visits within 4 weeks postoperatively, verbal rating pain scale (VRS), status of the angle by gonioscopy, and best corrected visual acuity (BCVA).RESULTS: There was no significant difference in IOP and BCVA between both groups. There were more patients who reported a VRS score of more than 3 in the physostigmine group (P=0.021). PAS or (anterior) lens dislocation was not observed.CONCLUSION: In eyes without co-morbidity, the routine use of physostigmine ointment has lost its rationale.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Female
KW - Gonioscopy
KW - Humans
KW - Intraocular Pressure/drug effects
KW - Lens Subluxation/etiology
KW - Male
KW - Middle Aged
KW - Miotics/administration & dosage
KW - Ocular Hypertension/etiology
KW - Ointments
KW - Pain Measurement
KW - Phacoemulsification/adverse effects
KW - Physostigmine/administration & dosage
KW - Prospective Studies
KW - Tissue Adhesions/etiology
KW - Treatment Outcome
KW - Visual Acuity/drug effects
U2 - 10.1089/jop.2011.0077
DO - 10.1089/jop.2011.0077
M3 - Article
C2 - 22029576
SN - 1080-7683
VL - 28
SP - 98
EP - 101
JO - Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
JF - Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
IS - 2
ER -