TY - JOUR
T1 - Immune electron microscopy and a cultural test in the diagnosis of adenovirus ocular infection
AU - Van Rij, G
AU - Klepper, L
AU - Peperkamp, E
AU - Schaap, G J
PY - 1982/5
Y1 - 1982/5
N2 - Immune electron microscopy (IEM) and virus isolation in cell culture were compared in the diagnosis of adenovirus ocular infection during an outbreak of the disease in 1979. Eleven of 14 patients with a keratoconjunctivitis clinically indicative of adenovirus infection had IEM evidence of adenovirus infection or had the virus isolated from ocular swabs. The IEM was positive in 8 patients. Virus as isolated from 10 patients. IEM was positive in one culture negative patient. Since IEM provides a rapid and sensitive method for the detection of adenovirus in human tears, it may be a valuable diagnostic tool for the clinician.
AB - Immune electron microscopy (IEM) and virus isolation in cell culture were compared in the diagnosis of adenovirus ocular infection during an outbreak of the disease in 1979. Eleven of 14 patients with a keratoconjunctivitis clinically indicative of adenovirus infection had IEM evidence of adenovirus infection or had the virus isolated from ocular swabs. The IEM was positive in 8 patients. Virus as isolated from 10 patients. IEM was positive in one culture negative patient. Since IEM provides a rapid and sensitive method for the detection of adenovirus in human tears, it may be a valuable diagnostic tool for the clinician.
KW - Adenoviridae Infections/diagnosis
KW - Adenovirus Infections, Human/diagnosis
KW - Adenoviruses, Human/isolation & purification
KW - Humans
KW - Keratoconjunctivitis/diagnosis
KW - Microscopy, Electron
KW - Tears/microbiology
U2 - 10.1136/bjo.66.5.317
DO - 10.1136/bjo.66.5.317
M3 - Article
C2 - 6280747
SN - 0007-1161
VL - 66
SP - 317
EP - 319
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 5
ER -