High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Elodie Bousquet; Camille Chenevier-Gobeaux; Thara Jaworski; Héloïse Torres-Villaros; Marta Zola; Irmela Mantel; Laura Kowalczuk; Alexandre Matet; Alejandra Daruich; Min Zhao; Suzanne Yzer; Francine Behar-Cohen

doi:10.1016/j.xops.2023.100278

High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Elodie Bousquet, Camille Chenevier-Gobeaux, Thara Jaworski, Héloïse Torres-Villaros, Marta Zola, Irmela Mantel, Laura Kowalczuk, Alexandre Matet, Alejandra Daruich, Min Zhao, Suzanne Yzer, Francine Behar-Cohen

Medical retina and Uveitis

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › Onderzoek › peer review

Samenvatting

PURPOSE: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.

DESIGN: Cross-sectional multicenter study.

PARTICIPANTS: Patients with CSCR compared with age- and sex-matched healthy participants.

METHODS: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.

MAIN OUTCOME MEASURES: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.

RESULTS: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.

CONCLUSIONS: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.

FINANCIAL DISCLOSURES: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Originele taal-2	Engels
Pagina's (van-tot)	100278
Tijdschrift	Ophthalmology Science
Volume	3
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.xops.2023.100278
Status	Gepubliceerd - sep. 2023

Toegang tot document

10.1016/j.xops.2023.100278

Citeer dit

Bousquet, E., Chenevier-Gobeaux, C., Jaworski, T., Torres-Villaros, H., Zola, M., Mantel, I., Kowalczuk, L., Matet, A., Daruich, A., Zhao, M., Yzer, S., & Behar-Cohen, F. (2023). High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy. Ophthalmology Science, 3(3), 100278. https://doi.org/10.1016/j.xops.2023.100278

@article{550c2389c664485dab9182687af483f7,

title = "High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy",

abstract = "PURPOSE: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.DESIGN: Cross-sectional multicenter study.PARTICIPANTS: Patients with CSCR compared with age- and sex-matched healthy participants.METHODS: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.MAIN OUTCOME MEASURES: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.RESULTS: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.CONCLUSIONS: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.FINANCIAL DISCLOSURES: The author(s) have no proprietary or commercial interest in any materials discussed in this article.",

author = "Elodie Bousquet and Camille Chenevier-Gobeaux and Thara Jaworski and H{\'e}lo{\"i}se Torres-Villaros and Marta Zola and Irmela Mantel and Laura Kowalczuk and Alexandre Matet and Alejandra Daruich and Min Zhao and Suzanne Yzer and Francine Behar-Cohen",

note = "{\textcopyright} 2023 Published by Elsevier Inc. on behalf of American Academy of Ophthalmology.",

year = "2023",

month = sep,

doi = "10.1016/j.xops.2023.100278",

language = "English",

volume = "3",

pages = "100278",

number = "3",

}

Bousquet, E, Chenevier-Gobeaux, C, Jaworski, T, Torres-Villaros, H, Zola, M, Mantel, I, Kowalczuk, L, Matet, A, Daruich, A, Zhao, M, Yzer, S & Behar-Cohen, F 2023, 'High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy', Ophthalmology Science, vol. 3, nr. 3, blz. 100278. https://doi.org/10.1016/j.xops.2023.100278

TY - JOUR

T1 - High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

AU - Bousquet, Elodie

AU - Chenevier-Gobeaux, Camille

AU - Jaworski, Thara

AU - Torres-Villaros, Héloïse

AU - Zola, Marta

AU - Mantel, Irmela

AU - Kowalczuk, Laura

AU - Matet, Alexandre

AU - Daruich, Alejandra

AU - Zhao, Min

AU - Yzer, Suzanne

AU - Behar-Cohen, Francine

PY - 2023/9

Y1 - 2023/9

N2 - PURPOSE: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.DESIGN: Cross-sectional multicenter study.PARTICIPANTS: Patients with CSCR compared with age- and sex-matched healthy participants.METHODS: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.MAIN OUTCOME MEASURES: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.RESULTS: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.CONCLUSIONS: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.FINANCIAL DISCLOSURES: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - PURPOSE: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.DESIGN: Cross-sectional multicenter study.PARTICIPANTS: Patients with CSCR compared with age- and sex-matched healthy participants.METHODS: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.MAIN OUTCOME MEASURES: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.RESULTS: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.CONCLUSIONS: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.FINANCIAL DISCLOSURES: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

U2 - 10.1016/j.xops.2023.100278

DO - 10.1016/j.xops.2023.100278

M3 - Article

C2 - 36950301

VL - 3

SP - 100278

IS - 3

ER -

High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit