Glaucoma in and out of Africa

This thesis describes epidemiologic and genetic studies on primary open-angle glaucoma in primarily sub-Saharan African, European and Asian populations. In the thesis, I aimed on the one hand to focus on sub-Saharan populations which are at high risk but underrepresented in clinical, epidemiological and genetic research. On the other hand, I aimed to explore novel approaches to study glaucoma endophenotypes. The major goals of our studies were
Chapter 2: to address differences in POAG phenotype in sub-Saharan African populations compared to European populations
Chapter 3: to identify genetic variants associated with POAG in sub-Saharan African populations
Chapter 4: to explore novel approaches to study genetic and phenotypic associations with glaucoma endophenotypes.