TY - JOUR
T1 - Azathioprine and prednisone combination treatment for adult periocular and orbital xanthogranulomatous disease
AU - Bijlsma, Ward R
AU - van den Bosch, Willem A
AU - van Daele, Paul L A
AU - Paridaens, Dion
N1 - © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.
PY - 2011/5
Y1 - 2011/5
N2 - PURPOSE: To report the authors' experience with azathioprine and prednisone combination for adult periocular and orbital xanthogranulomatous disease.METHODS: We identified 13 adults with histology-proven periocular or orbital xanthogranuloma in two tertiary referral orbital centres from 1984 to 2008. Patient records were reviewed and data collected on orbital localization, immune dysfunction, applied treatment and outcome.RESULTS: Five patients with periocular or orbital xanthogranulomatous disease were fully treated with prednisone and azathioprine combination, which resulted in stabilization in two and regression in three. Two other patients had to discontinue azathioprine because of side-effects. Of the non-fully treated prednisone/azathioprine patients, four out of eight progressed.CONCLUSION: In adult periocular and orbital xanthogranuloma, combined treatment with prednisone and azathioprine yields adequate immunosuppression, often for a prolonged period of time.
AB - PURPOSE: To report the authors' experience with azathioprine and prednisone combination for adult periocular and orbital xanthogranulomatous disease.METHODS: We identified 13 adults with histology-proven periocular or orbital xanthogranuloma in two tertiary referral orbital centres from 1984 to 2008. Patient records were reviewed and data collected on orbital localization, immune dysfunction, applied treatment and outcome.RESULTS: Five patients with periocular or orbital xanthogranulomatous disease were fully treated with prednisone and azathioprine combination, which resulted in stabilization in two and regression in three. Two other patients had to discontinue azathioprine because of side-effects. Of the non-fully treated prednisone/azathioprine patients, four out of eight progressed.CONCLUSION: In adult periocular and orbital xanthogranuloma, combined treatment with prednisone and azathioprine yields adequate immunosuppression, often for a prolonged period of time.
KW - Adult
KW - Aged
KW - Azathioprine/therapeutic use
KW - Conjunctival Diseases/drug therapy
KW - Drug Therapy, Combination
KW - Eye Diseases/drug therapy
KW - Eyelid Diseases/drug therapy
KW - Female
KW - Glucocorticoids/therapeutic use
KW - Granuloma/drug therapy
KW - Humans
KW - Immunosuppressive Agents/therapeutic use
KW - Lacrimal Apparatus Diseases/drug therapy
KW - Male
KW - Middle Aged
KW - Orbital Diseases/drug therapy
KW - Prednisone/therapeutic use
KW - Treatment Outcome
KW - Xanthomatosis/drug therapy
U2 - 10.1111/j.1755-3768.2009.01726.x
DO - 10.1111/j.1755-3768.2009.01726.x
M3 - Article
C2 - 19878126
SN - 1755-375X
VL - 89
SP - e278-82
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 3
ER -