Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

M Wefers Bettink-Remeijer; K Brouwers; L van Langenhove; P W T De Waard; T O Missotten; J P Martinez Ciriano; E Van Aken

doi:10.1038/eye.2009.234

Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

M Wefers Bettink-Remeijer, K Brouwers, L van Langenhove, P W T De Waard, T O Missotten, J P Martinez Ciriano, E Van Aken

Research output: Contribution to journal › Letter › peer-review

Abstract

OBJECTIVE: To report a newly recognized adverse effect of oral moxifloxacin.

DESIGN: Observational case reports.

PARTICIPANTS: Five patients who used oral moxifloxacin therapy.

MAIN OUTCOME MEASURES: In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.

CONCLUSIONS: Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.

Original language	English
Pages (from-to)	2260-2
Number of pages	3
Journal	Eye (London, England)
Volume	23
Issue number	12
DOIs	https://doi.org/10.1038/eye.2009.234
Publication status	Published - Dec 2009

Keywords

Administration, Oral
Adult
Aged
Anti-Infective Agents/adverse effects
Aza Compounds/adverse effects
Female
Fluoroquinolones
Humans
Iris Diseases/chemically induced
Male
Moxifloxacin
Photophobia/etiology
Quinolines/adverse effects
Transillumination
Uveitis/chemically induced

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10.1038/eye.2009.234

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title = "Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin",

abstract = "OBJECTIVE: To report a newly recognized adverse effect of oral moxifloxacin.DESIGN: Observational case reports.PARTICIPANTS: Five patients who used oral moxifloxacin therapy.MAIN OUTCOME MEASURES: In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.CONCLUSIONS: Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.",

keywords = "Administration, Oral, Adult, Aged, Anti-Infective Agents/adverse effects, Aza Compounds/adverse effects, Female, Fluoroquinolones, Humans, Iris Diseases/chemically induced, Male, Moxifloxacin, Photophobia/etiology, Quinolines/adverse effects, Transillumination, Uveitis/chemically induced",

author = "{Wefers Bettink-Remeijer}, M and K Brouwers and {van Langenhove}, L and {De Waard}, {P W T} and Missotten, {T O} and {Martinez Ciriano}, {J P} and {Van Aken}, E",

year = "2009",

month = dec,

doi = "10.1038/eye.2009.234",

language = "English",

volume = "23",

pages = "2260--2",

number = "12",

}

TY - JOUR

T1 - Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

AU - Wefers Bettink-Remeijer, M

AU - Brouwers, K

AU - van Langenhove, L

AU - De Waard, P W T

AU - Missotten, T O

AU - Martinez Ciriano, J P

AU - Van Aken, E

PY - 2009/12

Y1 - 2009/12

N2 - OBJECTIVE: To report a newly recognized adverse effect of oral moxifloxacin.DESIGN: Observational case reports.PARTICIPANTS: Five patients who used oral moxifloxacin therapy.MAIN OUTCOME MEASURES: In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.CONCLUSIONS: Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.

AB - OBJECTIVE: To report a newly recognized adverse effect of oral moxifloxacin.DESIGN: Observational case reports.PARTICIPANTS: Five patients who used oral moxifloxacin therapy.MAIN OUTCOME MEASURES: In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, not restricted to one sector, and persistent mydriasis of the pupil, with no reaction to light and no near reflex. Follow-up of 3 years in one of the patients showed no change of symptoms. Only in one patient, with a history of anterior uveitis, an anterior chamber tap was positive for herpes simplex genome. Only after the use of moxifloxacin did she experience continuous photophobia.CONCLUSIONS: Iris transillumination and sphincter paralysis is a newly recognized adverse effect of oral moxifloxacin therapy.

KW - Administration, Oral

KW - Adult

KW - Aged

KW - Anti-Infective Agents/adverse effects

KW - Aza Compounds/adverse effects

KW - Female

KW - Fluoroquinolones

KW - Humans

KW - Iris Diseases/chemically induced

KW - Male

KW - Moxifloxacin

KW - Photophobia/etiology

KW - Quinolines/adverse effects

KW - Transillumination

KW - Uveitis/chemically induced

U2 - 10.1038/eye.2009.234

DO - 10.1038/eye.2009.234

M3 - Letter

C2 - 19851342

SN - 0950-222X

VL - 23

SP - 2260

EP - 2262

JO - Eye (London, England)

JF - Eye (London, England)

IS - 12

ER -

Uveitis-like syndrome and iris transillumination after the use of oral moxifloxacin

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Keywords

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