Abstract
Introduction: Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a high-grade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs.
Case presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma.
Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.
Case presentation: In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma.
Conclusion: Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.
| Original language | English |
|---|---|
| Article number | Ocul Oncol Pathol (2024) 10 (4): 227–233. |
| Pages (from-to) | 227–233 |
| Journal | Ocular Oncology and Pathology |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 10 Dec 2024 |
Keywords
- Adult ocular oncology;
- Adult ocular tumours
- Intraocular tumours
- Ocular oncology
- Orbital tumour
- Sarcoma