Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma

Luana Cahya Ugahary; Elisabeth Ganteris; Marc Veckeneer; Adam C Cohen; Jan Jansen; Paul G H Mulder; Jan C van Meurs

doi:10.1016/j.ajo.2005.09.034

Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma

Luana Cahya Ugahary, Elisabeth Ganteris, Marc Veckeneer, Adam C Cohen, Jan Jansen, Paul G H Mulder, Jan C van Meurs

Vitreoretinal surgery

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.

DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.

METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.

RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.

CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

Original language	English
Pages (from-to)	571-3
Number of pages	3
Journal	American Journal of Ophthalmology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1016/j.ajo.2005.09.034
Publication status	Published - Mar 2006

Keywords

Administration, Topical
Adult
Aged
Chronic Disease
Cross-Over Studies
Deoxyepinephrine/administration & dosage
Dopamine Agonists/administration & dosage
Double-Blind Method
Eye Injuries, Penetrating/complications
Female
Humans
Intraocular Pressure/drug effects
Male
Middle Aged
Ocular Hypotension/drug therapy
Prospective Studies
Tonometry, Ocular
Uveitis/complications
Visual Acuity
Vitrectomy/adverse effects

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10.1016/j.ajo.2005.09.034

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@article{562ff8fc7e9e472591cf36a0b451cbac,

title = "Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma",

abstract = "PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.METHODS: In ten patients with ocular hypotony, an ibopamine 2\% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95\% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.CONCLUSIONS: The results of the study show that an ibopamine 2\% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.",

keywords = "Administration, Topical, Adult, Aged, Chronic Disease, Cross-Over Studies, Deoxyepinephrine/administration \& dosage, Dopamine Agonists/administration \& dosage, Double-Blind Method, Eye Injuries, Penetrating/complications, Female, Humans, Intraocular Pressure/drug effects, Male, Middle Aged, Ocular Hypotension/drug therapy, Prospective Studies, Tonometry, Ocular, Uveitis/complications, Visual Acuity, Vitrectomy/adverse effects",

author = "Ugahary, \{Luana Cahya\} and Elisabeth Ganteris and Marc Veckeneer and Cohen, \{Adam C\} and Jan Jansen and Mulder, \{Paul G H\} and \{van Meurs\}, \{Jan C\}",

year = "2006",

month = mar,

doi = "10.1016/j.ajo.2005.09.034",

language = "English",

volume = "141",

pages = "571--3",

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TY - JOUR

T1 - Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma

AU - Ugahary, Luana Cahya

AU - Ganteris, Elisabeth

AU - Veckeneer, Marc

AU - Cohen, Adam C

AU - Jansen, Jan

AU - Mulder, Paul G H

AU - van Meurs, Jan C

PY - 2006/3

Y1 - 2006/3

N2 - PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

AB - PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

KW - Administration, Topical

KW - Adult

KW - Aged

KW - Chronic Disease

KW - Cross-Over Studies

KW - Deoxyepinephrine/administration & dosage

KW - Dopamine Agonists/administration & dosage

KW - Double-Blind Method

KW - Eye Injuries, Penetrating/complications

KW - Female

KW - Humans

KW - Intraocular Pressure/drug effects

KW - Male

KW - Middle Aged

KW - Ocular Hypotension/drug therapy

KW - Prospective Studies

KW - Tonometry, Ocular

KW - Uveitis/complications

KW - Visual Acuity

KW - Vitrectomy/adverse effects

U2 - 10.1016/j.ajo.2005.09.034

DO - 10.1016/j.ajo.2005.09.034

M3 - Article

C2 - 16490513

SN - 0002-9394

VL - 141

SP - 571

EP - 573

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 3

ER -

Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma

Abstract

Keywords

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