PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.
DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.
METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.
RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.
CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.
|Number of pages||3|
|Journal||American Journal of Ophthalmology|
|Publication status||Published - Mar 2006|
- Administration, Topical
- Chronic Disease
- Cross-Over Studies
- Deoxyepinephrine/administration & dosage
- Dopamine Agonists/administration & dosage
- Double-Blind Method
- Eye Injuries, Penetrating/complications
- Intraocular Pressure/drug effects
- Middle Aged
- Ocular Hypotension/drug therapy
- Prospective Studies
- Tonometry, Ocular
- Visual Acuity
- Vitrectomy/adverse effects