Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma

Luana Cahya Ugahary, Elisabeth Ganteris, Marc Veckeneer, Adam C Cohen, Jan Jansen, Paul G H Mulder, Jan C van Meurs

Research output: Contribution to journalArticleResearchpeer-review

Abstract

PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.

DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study.

METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.

RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.

CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

Original languageEnglish
Pages (from-to)571-3
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume141
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Administration, Topical
  • Adult
  • Aged
  • Chronic Disease
  • Cross-Over Studies
  • Deoxyepinephrine/administration & dosage
  • Dopamine Agonists/administration & dosage
  • Double-Blind Method
  • Eye Injuries, Penetrating/complications
  • Female
  • Humans
  • Intraocular Pressure/drug effects
  • Male
  • Middle Aged
  • Ocular Hypotension/drug therapy
  • Prospective Studies
  • Tonometry, Ocular
  • Uveitis/complications
  • Visual Acuity
  • Vitrectomy/adverse effects

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