Abstract
PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.
METHOD: Interventional case report.
RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.
CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.
Original language | English |
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Pages (from-to) | 1613-1615 |
Number of pages | 3 |
Journal | International Ophthalmology |
Volume | 39 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2019 |
Keywords
- Administration, Topical
- Biopsy
- Eyelids/pathology
- Female
- Glucocorticoids/administration & dosage
- Humans
- Immunoglobulin G4-Related Disease/complications
- Middle Aged
- Neurocutaneous Syndromes/diagnosis
- Pigmentation Disorders/diagnosis