PURPOSE: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.
METHOD: Interventional case report.
RESULTS: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.
CONCLUSIONS: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.
|Number of pages||3|
|Publication status||Published - Jul 2019|
- Administration, Topical
- Glucocorticoids/administration & dosage
- Immunoglobulin G4-Related Disease/complications
- Middle Aged
- Neurocutaneous Syndromes/diagnosis
- Pigmentation Disorders/diagnosis