The ability of short-wavelength automated perimetry to predict conversion to glaucoma

Josine van der Schoot; Nicolaas J Reus; Thomas P Colen; Hans G Lemij

doi:10.1016/j.ophtha.2009.06.046

The ability of short-wavelength automated perimetry to predict conversion to glaucoma

Josine van der Schoot, Nicolaas J Reus, Thomas P Colen, Hans G Lemij

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: Short-wavelength automated perimetry (SWAP) has been claimed to predict conversion to glaucoma 3 to 4 years before standard automated perimetry (SAP) defects occur. This study compared the moment of glaucomatous conversion between SWAP and SAP.

DESIGN: Prospective, longitudinal follow-up study.

PARTICIPANTS: Four hundred sixteen subjects with ocular hypertension (intraocular pressure >/=22 and </=32 mmHg and normal visual fields).

METHODS: A Humphrey Field Analyzer (24-2 program; Carl Zeiss Meditec, Dublin, CA) was used to perform both SWAP and SAP. All participants were tested once every half year during 7 to 10 years or until the onset of conversion (study end point). The conversion to glaucoma was defined as a reproducible glaucomatous visual field defect in SAP.

MAIN OUTCOME MEASURES: The moment of onset of a reproducible defect in SAP was compared with that in SWAP.

RESULTS: Of the 416 initial participants, 24 eyes of 21 subjects showed conversion in SAP. Of these eyes, 22 did not show earlier conversion in SWAP than in SAP. Standard automated perimetry even showed earlier conversion than SWAP in 15 cases. In only 2 eyes did SWAP show earlier conversion by up to 18 months.

CONCLUSIONS: These results do not support the notion that SWAP generally predicts conversion to glaucoma in SAP. Instead, SAP appears to be at least as sensitive to conversion as SWAP in a large majority of eyes.

FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Original language	English
Pages (from-to)	30-4
Number of pages	5
Journal	Ophthalmology
Volume	117
Issue number	1
DOIs	https://doi.org/10.1016/j.ophtha.2009.06.046
Publication status	Published - Jan 2010

Keywords

Aged
Antihypertensive Agents/administration & dosage
Betaxolol/administration & dosage
Double-Blind Method
Female
Follow-Up Studies
Glaucoma/diagnosis
Humans
Intraocular Pressure/physiology
Male
Middle Aged
Nerve Fibers/pathology
Ocular Hypertension/diagnosis
Optic Nerve Diseases/diagnosis
Prospective Studies
Retinal Ganglion Cells/pathology
Timolol/administration & dosage
Vision Disorders/diagnosis
Visual Field Tests/methods
Visual Fields

Access to Document

10.1016/j.ophtha.2009.06.046

Cite this

@article{9da6a18383344b42a52c443b1cc46084,

title = "The ability of short-wavelength automated perimetry to predict conversion to glaucoma",

abstract = "PURPOSE: Short-wavelength automated perimetry (SWAP) has been claimed to predict conversion to glaucoma 3 to 4 years before standard automated perimetry (SAP) defects occur. This study compared the moment of glaucomatous conversion between SWAP and SAP.DESIGN: Prospective, longitudinal follow-up study.PARTICIPANTS: Four hundred sixteen subjects with ocular hypertension (intraocular pressure >/=22 and </=32 mmHg and normal visual fields).METHODS: A Humphrey Field Analyzer (24-2 program; Carl Zeiss Meditec, Dublin, CA) was used to perform both SWAP and SAP. All participants were tested once every half year during 7 to 10 years or until the onset of conversion (study end point). The conversion to glaucoma was defined as a reproducible glaucomatous visual field defect in SAP.MAIN OUTCOME MEASURES: The moment of onset of a reproducible defect in SAP was compared with that in SWAP.RESULTS: Of the 416 initial participants, 24 eyes of 21 subjects showed conversion in SAP. Of these eyes, 22 did not show earlier conversion in SWAP than in SAP. Standard automated perimetry even showed earlier conversion than SWAP in 15 cases. In only 2 eyes did SWAP show earlier conversion by up to 18 months.CONCLUSIONS: These results do not support the notion that SWAP generally predicts conversion to glaucoma in SAP. Instead, SAP appears to be at least as sensitive to conversion as SWAP in a large majority of eyes.FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.",

keywords = "Aged, Antihypertensive Agents/administration & dosage, Betaxolol/administration & dosage, Double-Blind Method, Female, Follow-Up Studies, Glaucoma/diagnosis, Humans, Intraocular Pressure/physiology, Male, Middle Aged, Nerve Fibers/pathology, Ocular Hypertension/diagnosis, Optic Nerve Diseases/diagnosis, Prospective Studies, Retinal Ganglion Cells/pathology, Timolol/administration & dosage, Vision Disorders/diagnosis, Visual Field Tests/methods, Visual Fields",

author = "{van der Schoot}, Josine and Reus, {Nicolaas J} and Colen, {Thomas P} and Lemij, {Hans G}",

year = "2010",

month = jan,

doi = "10.1016/j.ophtha.2009.06.046",

language = "English",

volume = "117",

pages = "30--4",

number = "1",

}

TY - JOUR

T1 - The ability of short-wavelength automated perimetry to predict conversion to glaucoma

AU - van der Schoot, Josine

AU - Reus, Nicolaas J

AU - Colen, Thomas P

AU - Lemij, Hans G

PY - 2010/1

Y1 - 2010/1

N2 - PURPOSE: Short-wavelength automated perimetry (SWAP) has been claimed to predict conversion to glaucoma 3 to 4 years before standard automated perimetry (SAP) defects occur. This study compared the moment of glaucomatous conversion between SWAP and SAP.DESIGN: Prospective, longitudinal follow-up study.PARTICIPANTS: Four hundred sixteen subjects with ocular hypertension (intraocular pressure >/=22 and </=32 mmHg and normal visual fields).METHODS: A Humphrey Field Analyzer (24-2 program; Carl Zeiss Meditec, Dublin, CA) was used to perform both SWAP and SAP. All participants were tested once every half year during 7 to 10 years or until the onset of conversion (study end point). The conversion to glaucoma was defined as a reproducible glaucomatous visual field defect in SAP.MAIN OUTCOME MEASURES: The moment of onset of a reproducible defect in SAP was compared with that in SWAP.RESULTS: Of the 416 initial participants, 24 eyes of 21 subjects showed conversion in SAP. Of these eyes, 22 did not show earlier conversion in SWAP than in SAP. Standard automated perimetry even showed earlier conversion than SWAP in 15 cases. In only 2 eyes did SWAP show earlier conversion by up to 18 months.CONCLUSIONS: These results do not support the notion that SWAP generally predicts conversion to glaucoma in SAP. Instead, SAP appears to be at least as sensitive to conversion as SWAP in a large majority of eyes.FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - PURPOSE: Short-wavelength automated perimetry (SWAP) has been claimed to predict conversion to glaucoma 3 to 4 years before standard automated perimetry (SAP) defects occur. This study compared the moment of glaucomatous conversion between SWAP and SAP.DESIGN: Prospective, longitudinal follow-up study.PARTICIPANTS: Four hundred sixteen subjects with ocular hypertension (intraocular pressure >/=22 and </=32 mmHg and normal visual fields).METHODS: A Humphrey Field Analyzer (24-2 program; Carl Zeiss Meditec, Dublin, CA) was used to perform both SWAP and SAP. All participants were tested once every half year during 7 to 10 years or until the onset of conversion (study end point). The conversion to glaucoma was defined as a reproducible glaucomatous visual field defect in SAP.MAIN OUTCOME MEASURES: The moment of onset of a reproducible defect in SAP was compared with that in SWAP.RESULTS: Of the 416 initial participants, 24 eyes of 21 subjects showed conversion in SAP. Of these eyes, 22 did not show earlier conversion in SWAP than in SAP. Standard automated perimetry even showed earlier conversion than SWAP in 15 cases. In only 2 eyes did SWAP show earlier conversion by up to 18 months.CONCLUSIONS: These results do not support the notion that SWAP generally predicts conversion to glaucoma in SAP. Instead, SAP appears to be at least as sensitive to conversion as SWAP in a large majority of eyes.FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

KW - Aged

KW - Antihypertensive Agents/administration & dosage

KW - Betaxolol/administration & dosage

KW - Double-Blind Method

KW - Female

KW - Follow-Up Studies

KW - Glaucoma/diagnosis

KW - Humans

KW - Intraocular Pressure/physiology

KW - Male

KW - Middle Aged

KW - Nerve Fibers/pathology

KW - Ocular Hypertension/diagnosis

KW - Optic Nerve Diseases/diagnosis

KW - Prospective Studies

KW - Retinal Ganglion Cells/pathology

KW - Timolol/administration & dosage

KW - Vision Disorders/diagnosis

KW - Visual Field Tests/methods

KW - Visual Fields

U2 - 10.1016/j.ophtha.2009.06.046

DO - 10.1016/j.ophtha.2009.06.046

M3 - Article

C2 - 19896194

SN - 0161-6420

VL - 117

SP - 30

EP - 34

JO - Ophthalmology

JF - Ophthalmology

IS - 1

ER -

The ability of short-wavelength automated perimetry to predict conversion to glaucoma

Abstract

Keywords

Access to Document

Fingerprint

Cite this