Somatostatin and somatostatin receptors in retinal diseases

P M van Hagen; G S Baarsma; C M Mooy; E M Ercoskan; E ter Averst; L J Hofland; S W Lamberts; R W Kuijpers

doi:10.1530/eje.0.143s043

Somatostatin and somatostatin receptors in retinal diseases

P M van Hagen, G S Baarsma, C M Mooy, E M Ercoskan, E ter Averst, L J Hofland, S W Lamberts, R W Kuijpers

Medical retina and Uveitis

Research output: Contribution to journal › Review article › peer-review

Abstract

Somatostatin is a small neuropeptide that is produced in the central nervous system, where it acts as a neurotransmitter. This neuropeptide also has an important role in the neuroendocrine system as an inhibitor of hormone release, the most striking example of which is the inhibition of growth hormone release. The role of somatostatin in eye disease recently became of interest because of its role in proliferative diabetic retinopathy and cystoid macularoedema(1-3). In this paper, we discuss the role of somatostatin in the retina and also present preliminary results of treatment of exudative age-related macular disease with the somatostatin analogue, octreotide.

Original language	English
Pages (from-to)	S43-51
Number of pages	9
Journal	European Journal of Endocrinology
Volume	143
Issue number	Suppl 1
DOIs	https://doi.org/10.1530/eje.0.143s043
Publication status	Published - Oct 2000

Keywords

Adult
Aged
Aging
Animals
Female
Humans
Insulin-Like Growth Factor I/physiology
Male
Middle Aged
Receptors, Somatostatin/physiology
Retinal Diseases/physiopathology
Somatostatin/physiology

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10.1530/eje.0.143s043

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title = "Somatostatin and somatostatin receptors in retinal diseases",

abstract = "Somatostatin is a small neuropeptide that is produced in the central nervous system, where it acts as a neurotransmitter. This neuropeptide also has an important role in the neuroendocrine system as an inhibitor of hormone release, the most striking example of which is the inhibition of growth hormone release. The role of somatostatin in eye disease recently became of interest because of its role in proliferative diabetic retinopathy and cystoid macularoedema(1-3). In this paper, we discuss the role of somatostatin in the retina and also present preliminary results of treatment of exudative age-related macular disease with the somatostatin analogue, octreotide.",

keywords = "Adult, Aged, Aging, Animals, Female, Humans, Insulin-Like Growth Factor I/physiology, Male, Middle Aged, Receptors, Somatostatin/physiology, Retinal Diseases/physiopathology, Somatostatin/physiology",

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year = "2000",

month = oct,

doi = "10.1530/eje.0.143s043",

language = "English",

volume = "143",

pages = "S43--51",

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TY - JOUR

T1 - Somatostatin and somatostatin receptors in retinal diseases

AU - van Hagen, P M

AU - Baarsma, G S

AU - Mooy, C M

AU - Ercoskan, E M

AU - ter Averst, E

AU - Hofland, L J

AU - Lamberts, S W

AU - Kuijpers, R W

PY - 2000/10

Y1 - 2000/10

N2 - Somatostatin is a small neuropeptide that is produced in the central nervous system, where it acts as a neurotransmitter. This neuropeptide also has an important role in the neuroendocrine system as an inhibitor of hormone release, the most striking example of which is the inhibition of growth hormone release. The role of somatostatin in eye disease recently became of interest because of its role in proliferative diabetic retinopathy and cystoid macularoedema(1-3). In this paper, we discuss the role of somatostatin in the retina and also present preliminary results of treatment of exudative age-related macular disease with the somatostatin analogue, octreotide.

AB - Somatostatin is a small neuropeptide that is produced in the central nervous system, where it acts as a neurotransmitter. This neuropeptide also has an important role in the neuroendocrine system as an inhibitor of hormone release, the most striking example of which is the inhibition of growth hormone release. The role of somatostatin in eye disease recently became of interest because of its role in proliferative diabetic retinopathy and cystoid macularoedema(1-3). In this paper, we discuss the role of somatostatin in the retina and also present preliminary results of treatment of exudative age-related macular disease with the somatostatin analogue, octreotide.

KW - Adult

KW - Aged

KW - Aging

KW - Animals

KW - Female

KW - Humans

KW - Insulin-Like Growth Factor I/physiology

KW - Male

KW - Middle Aged

KW - Receptors, Somatostatin/physiology

KW - Retinal Diseases/physiopathology

KW - Somatostatin/physiology

U2 - 10.1530/eje.0.143s043

DO - 10.1530/eje.0.143s043

M3 - Review article

C2 - 11068939

SN - 0804-4643

VL - 143

SP - S43-51

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - Suppl 1

ER -

Somatostatin and somatostatin receptors in retinal diseases

Abstract

Keywords

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