Self-limiting corneal edema with multiple parallel lines on the endothelium (SCEMPLE)

Sofie Le Piane, Toine Hillenaar, Lies Remeijer

Research output: Contribution to journalArticleProfessionalpeer-review


The purpose of this study was to report the natural course and in vivo confocal microscopy (IVCM) findings of five cases with unilateral self-limiting corneal edema and multiple parallel lines on the endothelium (SCEMPLE). This study is an observational case series. Five patients, who experienced a blurred vision due to SCEMPLE, were studied using slit-lamp examination and white-light IVCM (Confoscan 4; Nidek Technologies, Padova, Italy). IVCM of the linear deposits revealed characteristic hyperreflective material protruding between the endothelial cells. The lines also displayed spot-like holes and polygonal precipitates, which resembled dislodged endothelial cells. Because other signs of corneal inflammation, such as stromal infiltration and ciliary injection, were lacking, the condition was left untreated. After 1 day, slit-lamp examination and IVCM revealed only a small residual of the lines. Spontaneous, complete resolution occurred in all five cases within 1 week, leaving a lower endothelial cell density of the affected eyes as only sequela. SCEMPLE requires no treatment but may result in endothelial cell loss. The self-limiting character and IVCM appearance dispute SCEMPLE being a form of endotheliitis and suggest a different etiology.

Original languageEnglish
Pages (from-to)1279-84
Number of pages6
JournalInternational Ophthalmology
Issue number6
Publication statusPublished - Dec 2014


  • Aged
  • Aged, 80 and over
  • Corneal Edema/pathology
  • Endothelium, Corneal/pathology
  • Female
  • Humans
  • Male
  • Microscopy, Confocal
  • Middle Aged


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