Retinal vasculitis occurring with common variable immunodeficiency syndrome

J C van Meurs; S Lightman; P W de Waard; G S Baarsma; L W van Suijlekom-Smit; J P van de Merwe; R de Groot

doi:10.1016/s0002-9394(99)00325-6

Retinal vasculitis occurring with common variable immunodeficiency syndrome

J C van Meurs, S Lightman, P W de Waard, G S Baarsma, L W van Suijlekom-Smit, J P van de Merwe, R de Groot

Research output: Contribution to journal › Letter › peer-review

Abstract

PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.

METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.

RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).

CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.

Original language	English
Pages (from-to)	269-70
Number of pages	2
Journal	American Journal of Ophthalmology
Volume	129
Issue number	2
DOIs	https://doi.org/10.1016/s0002-9394(99)00325-6
Publication status	Published - Feb 2000

Keywords

Capillary Permeability
Child
Child, Preschool
Common Variable Immunodeficiency/complications
Cyclosporine/therapeutic use
Female
Glucocorticoids/therapeutic use
Humans
Macular Edema/drug therapy
Male
Retinal Diseases/drug therapy
Retinal Neovascularization/drug therapy
Retinal Vessels/pathology
Syndrome
Vasculitis/drug therapy
Vision Disorders/etiology
Visual Acuity

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10.1016/s0002-9394(99)00325-6

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@article{3178167991944b00b9d92b81d021f898,

title = "Retinal vasculitis occurring with common variable immunodeficiency syndrome",

abstract = "PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.",

keywords = "Capillary Permeability, Child, Child, Preschool, Common Variable Immunodeficiency/complications, Cyclosporine/therapeutic use, Female, Glucocorticoids/therapeutic use, Humans, Macular Edema/drug therapy, Male, Retinal Diseases/drug therapy, Retinal Neovascularization/drug therapy, Retinal Vessels/pathology, Syndrome, Vasculitis/drug therapy, Vision Disorders/etiology, Visual Acuity",

author = "{van Meurs}, {J C} and S Lightman and {de Waard}, {P W} and Baarsma, {G S} and {van Suijlekom-Smit}, {L W} and {van de Merwe}, {J P} and {de Groot}, R",

year = "2000",

month = feb,

doi = "10.1016/s0002-9394(99)00325-6",

language = "English",

volume = "129",

pages = "269--70",

number = "2",

}

TY - JOUR

T1 - Retinal vasculitis occurring with common variable immunodeficiency syndrome

AU - van Meurs, J C

AU - Lightman, S

AU - de Waard, P W

AU - Baarsma, G S

AU - van Suijlekom-Smit, L W

AU - van de Merwe, J P

AU - de Groot, R

PY - 2000/2

Y1 - 2000/2

N2 - PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.

AB - PURPOSE: To report severe retinal vasculitis causing decreased vision in three patients with the common variable immunodeficiency syndrome.METHOD: Case report. Three patients with common variable immunodeficiency syndrome developed decreased vision secondary to retinal vasculitis. Fluorescein angiography was performed in all three patients. Peribulbar injections were given in one patient, and two patients were treated with oral steroids and cyclosporin.RESULTS: All three patients were young and had classic common variable immunodeficiency syndrome. Bilateral retinal vasculitis and diffuse retinal edema were present in all three patients, and two patients had retinal neovascularization in the absence of ischemia. No evidence of intraocular infection was present, and none was detected systematically. Visual acuity decreased in five of the six eyes and was responsive to treatment in only one patient (both eyes).CONCLUSION: Retinal vasculitis may be another autoimmune manifestation of common variable immunodeficiency syndrome.

KW - Capillary Permeability

KW - Child

KW - Child, Preschool

KW - Common Variable Immunodeficiency/complications

KW - Cyclosporine/therapeutic use

KW - Female

KW - Glucocorticoids/therapeutic use

KW - Humans

KW - Macular Edema/drug therapy

KW - Male

KW - Retinal Diseases/drug therapy

KW - Retinal Neovascularization/drug therapy

KW - Retinal Vessels/pathology

KW - Syndrome

KW - Vasculitis/drug therapy

KW - Vision Disorders/etiology

KW - Visual Acuity

U2 - 10.1016/s0002-9394(99)00325-6

DO - 10.1016/s0002-9394(99)00325-6

M3 - Letter

C2 - 10682991

SN - 0002-9394

VL - 129

SP - 269

EP - 270

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 2

ER -

Retinal vasculitis occurring with common variable immunodeficiency syndrome

Abstract

Keywords

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