Abstract
AIM: To investigate whether retinal pigment epithelium (RPE)-choroid translocation would be a suitable treatment for RPE tears, which have a poor prognosis and are encountered more often since the introduction of anti-(vascular endothelial growth factor (VEGF)) therapy for exudative age-related macular degeneration (AMD).
METHODS: Prospective interventional case series of six eyes of six patients with AMD with an RPE tear treated with an RPE-choroid translocation. The RPE tear occurred in a vascularised pigment epithelium detachment in four patients and after treatment in the other two. Preoperative and postoperative evaluation included ETDRS visual acuity (VA) and fixation testing. The follow-up period ranged from 6 months to 2 years.
RESULTS: The mean preoperative VA was 20/160 (range 20/400-20/80). The mean VA at the last examination after surgery was 20/80 (range 1/60-20/50). One of the six patients had a preoperative VA of >/=20/80, and four had a VA of 20/80 or better at their last examination. Foveal fixation on the graft was present in five of the six eyes up to the last examination.
CONCLUSION: These preliminary data show that an RPE-choroid translocation may be a treatment option for patients with an RPE tear.
| Original language | English |
|---|---|
| Pages (from-to) | 526-9 |
| Number of pages | 4 |
| Journal | British Journal of Ophthalmology |
| Volume | 92 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2008 |
Keywords
- Aged
- Aged, 80 and over
- Choroid/transplantation
- Choroidal Neovascularization/complications
- Female
- Humans
- Macular Degeneration/complications
- Male
- Pigment Epithelium of Eye/injuries
- Postoperative Complications
- Prospective Studies
- Treatment Outcome
- Visual Acuity
- Vitrectomy