Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry

Nicolaas J Reus; Hans G Lemij

doi:10.1167/iovs.04-1029

Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry

Nicolaas J Reus, Hans G Lemij

Glaucoma

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: This study was designed to determine and compare the relationships between visual function measured with standard automated perimetry (SAP) and structure, either as neuroretinal rim area measured with confocal scanning laser ophthalmoscopy (CSLO), or as retinal nerve fiber layer thickness determined by scanning laser polarimetry with variable corneal compensation (SLP-VCC).

METHODS: Forty-six healthy subjects and 76 glaucoma patients were examined with SAP, with CSLO by means of the commercially available Heidelberg Retina Tomograph I (HRT), and with SLP-VCC by means of the commercially available GDx VCC. The relationships between SAP, expressed either in the typically used decibel scale or as number of abnormal points in the total deviation probability plot, and CSLO and between SAP and SLP-VCC were described with linear and logarithmic regression analysis for global data and six individual sectors. The relationship between measurements with CSLO and SLP-VCC was fit with linear regression analysis.

RESULTS: The relationships between SAP and CSLO and between SAP and SLP-VCC appeared curvilinear for all sectors except the temporal one between SAP and SLP-VCC. For CSLO, a logarithmic fit was significantly better than a linear one for the global data and in the superotemporal and inferonasal sectors. For SLP-VCC, a curvilinear fit was better for the global data and in the superotemporal, superonasal, and inferonasal sectors. CSLO data correlated linearly with SLP-VCC data in all sectors, except temporally.

CONCLUSIONS: CSLO and SLP-VCC showed a very similar curvilinear relationship with SAP. The observed curvilinear relationships confirm earlier reports that these imaging devices appear to detect glaucomatous loss earlier than SAP.

Original language	English
Pages (from-to)	4182-8
Number of pages	7
Journal	Investigative ophthalmology & visual science
Volume	46
Issue number	11
DOIs	https://doi.org/10.1167/iovs.04-1029
Publication status	Published - Nov 2005

Keywords

Birefringence
Female
Glaucoma, Open-Angle/diagnosis
Gonioscopy
Humans
Lasers
Male
Middle Aged
Nerve Fibers/pathology
Ophthalmoscopy/methods
Optic Nerve Diseases/diagnosis
Regression Analysis
Reproducibility of Results
Retinal Ganglion Cells/pathology
Tomography/methods
Vision Disorders/diagnosis
Visual Field Tests/methods
Visual Fields

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10.1167/iovs.04-1029

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title = "Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry",

abstract = "PURPOSE: This study was designed to determine and compare the relationships between visual function measured with standard automated perimetry (SAP) and structure, either as neuroretinal rim area measured with confocal scanning laser ophthalmoscopy (CSLO), or as retinal nerve fiber layer thickness determined by scanning laser polarimetry with variable corneal compensation (SLP-VCC).METHODS: Forty-six healthy subjects and 76 glaucoma patients were examined with SAP, with CSLO by means of the commercially available Heidelberg Retina Tomograph I (HRT), and with SLP-VCC by means of the commercially available GDx VCC. The relationships between SAP, expressed either in the typically used decibel scale or as number of abnormal points in the total deviation probability plot, and CSLO and between SAP and SLP-VCC were described with linear and logarithmic regression analysis for global data and six individual sectors. The relationship between measurements with CSLO and SLP-VCC was fit with linear regression analysis.RESULTS: The relationships between SAP and CSLO and between SAP and SLP-VCC appeared curvilinear for all sectors except the temporal one between SAP and SLP-VCC. For CSLO, a logarithmic fit was significantly better than a linear one for the global data and in the superotemporal and inferonasal sectors. For SLP-VCC, a curvilinear fit was better for the global data and in the superotemporal, superonasal, and inferonasal sectors. CSLO data correlated linearly with SLP-VCC data in all sectors, except temporally.CONCLUSIONS: CSLO and SLP-VCC showed a very similar curvilinear relationship with SAP. The observed curvilinear relationships confirm earlier reports that these imaging devices appear to detect glaucomatous loss earlier than SAP.",

keywords = "Birefringence, Female, Glaucoma, Open-Angle/diagnosis, Gonioscopy, Humans, Lasers, Male, Middle Aged, Nerve Fibers/pathology, Ophthalmoscopy/methods, Optic Nerve Diseases/diagnosis, Regression Analysis, Reproducibility of Results, Retinal Ganglion Cells/pathology, Tomography/methods, Vision Disorders/diagnosis, Visual Field Tests/methods, Visual Fields",

author = "Reus, {Nicolaas J} and Lemij, {Hans G}",

year = "2005",

month = nov,

doi = "10.1167/iovs.04-1029",

language = "English",

volume = "46",

pages = "4182--8",

number = "11",

}

TY - JOUR

T1 - Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry

AU - Reus, Nicolaas J

AU - Lemij, Hans G

PY - 2005/11

Y1 - 2005/11

N2 - PURPOSE: This study was designed to determine and compare the relationships between visual function measured with standard automated perimetry (SAP) and structure, either as neuroretinal rim area measured with confocal scanning laser ophthalmoscopy (CSLO), or as retinal nerve fiber layer thickness determined by scanning laser polarimetry with variable corneal compensation (SLP-VCC).METHODS: Forty-six healthy subjects and 76 glaucoma patients were examined with SAP, with CSLO by means of the commercially available Heidelberg Retina Tomograph I (HRT), and with SLP-VCC by means of the commercially available GDx VCC. The relationships between SAP, expressed either in the typically used decibel scale or as number of abnormal points in the total deviation probability plot, and CSLO and between SAP and SLP-VCC were described with linear and logarithmic regression analysis for global data and six individual sectors. The relationship between measurements with CSLO and SLP-VCC was fit with linear regression analysis.RESULTS: The relationships between SAP and CSLO and between SAP and SLP-VCC appeared curvilinear for all sectors except the temporal one between SAP and SLP-VCC. For CSLO, a logarithmic fit was significantly better than a linear one for the global data and in the superotemporal and inferonasal sectors. For SLP-VCC, a curvilinear fit was better for the global data and in the superotemporal, superonasal, and inferonasal sectors. CSLO data correlated linearly with SLP-VCC data in all sectors, except temporally.CONCLUSIONS: CSLO and SLP-VCC showed a very similar curvilinear relationship with SAP. The observed curvilinear relationships confirm earlier reports that these imaging devices appear to detect glaucomatous loss earlier than SAP.

AB - PURPOSE: This study was designed to determine and compare the relationships between visual function measured with standard automated perimetry (SAP) and structure, either as neuroretinal rim area measured with confocal scanning laser ophthalmoscopy (CSLO), or as retinal nerve fiber layer thickness determined by scanning laser polarimetry with variable corneal compensation (SLP-VCC).METHODS: Forty-six healthy subjects and 76 glaucoma patients were examined with SAP, with CSLO by means of the commercially available Heidelberg Retina Tomograph I (HRT), and with SLP-VCC by means of the commercially available GDx VCC. The relationships between SAP, expressed either in the typically used decibel scale or as number of abnormal points in the total deviation probability plot, and CSLO and between SAP and SLP-VCC were described with linear and logarithmic regression analysis for global data and six individual sectors. The relationship between measurements with CSLO and SLP-VCC was fit with linear regression analysis.RESULTS: The relationships between SAP and CSLO and between SAP and SLP-VCC appeared curvilinear for all sectors except the temporal one between SAP and SLP-VCC. For CSLO, a logarithmic fit was significantly better than a linear one for the global data and in the superotemporal and inferonasal sectors. For SLP-VCC, a curvilinear fit was better for the global data and in the superotemporal, superonasal, and inferonasal sectors. CSLO data correlated linearly with SLP-VCC data in all sectors, except temporally.CONCLUSIONS: CSLO and SLP-VCC showed a very similar curvilinear relationship with SAP. The observed curvilinear relationships confirm earlier reports that these imaging devices appear to detect glaucomatous loss earlier than SAP.

KW - Birefringence

KW - Female

KW - Glaucoma, Open-Angle/diagnosis

KW - Gonioscopy

KW - Humans

KW - Lasers

KW - Male

KW - Middle Aged

KW - Nerve Fibers/pathology

KW - Ophthalmoscopy/methods

KW - Optic Nerve Diseases/diagnosis

KW - Regression Analysis

KW - Reproducibility of Results

KW - Retinal Ganglion Cells/pathology

KW - Tomography/methods

KW - Vision Disorders/diagnosis

KW - Visual Field Tests/methods

KW - Visual Fields

U2 - 10.1167/iovs.04-1029

DO - 10.1167/iovs.04-1029

M3 - Article

C2 - 16249497

SN - 0146-0404

VL - 46

SP - 4182

EP - 4188

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

IS - 11

ER -

Relationships between standard automated perimetry, HRT confocal scanning laser ophthalmoscopy, and GDx VCC scanning laser polarimetry

Abstract

Keywords

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