Raised numbers of IgG4-positive plasma cells are a common histopathological finding in orbital xanthogranulomatous disease

Robert M Verdijk, Pegah Heidari, Roel Verschooten, Paul L van Daele, Huib J Simonsz, Dion Paridaens

Research output: Contribution to journalArticleResearchpeer-review

Abstract

PURPOSE: To determine the relation of orbital xanthogranuloma with IgG4-related disease.

METHODS: Retrospective consecutive case series over a period of 25 years. We searched our charts for histologically confirmed orbital xanthogranuloma. Patient files were reviewed for clinical and follow up data including presence or absence of systemic non-ophthalmic manifestations of IgG4 related disease. Slides were re-examined and histopathological classification was re-assessed. Sixteen cases of orbital xanthogranuloma were evaluated. Immunohistochemical stains for IgG and IgG4 were performed. Positive immunohistochemical staining required increased IgG4-positive plasma cells in the involved tissues scored as >50 per high-power field, with IgG4/IgG ratio >0.40.

RESULTS: According to the criteria described above 8/16 (50%) cases showed increased numbers of IgG4-positive plasma cells in the specimens. Two of these patients may have had signs of systemic disease.

CONCLUSION: Raised numbers of IgG4-positive plasma cells are a common finding in histopathological specimens of xanthogranulomatous disease of the orbit and are often not indicative for IgG4 related systemic disease.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalOrbit (Amsterdam, Netherlands)
Volume33
Issue number1
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Granuloma/blood
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin G/blood
  • Immunosuppressive Agents/therapeutic use
  • Lymphatic Diseases/blood
  • Male
  • Middle Aged
  • Orbital Diseases/blood
  • Plasma Cells/immunology
  • Retrospective Studies
  • Xanthomatosis/blood

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