PURPOSE: To determine the relation of orbital xanthogranuloma with IgG4-related disease.
METHODS: Retrospective consecutive case series over a period of 25 years. We searched our charts for histologically confirmed orbital xanthogranuloma. Patient files were reviewed for clinical and follow up data including presence or absence of systemic non-ophthalmic manifestations of IgG4 related disease. Slides were re-examined and histopathological classification was re-assessed. Sixteen cases of orbital xanthogranuloma were evaluated. Immunohistochemical stains for IgG and IgG4 were performed. Positive immunohistochemical staining required increased IgG4-positive plasma cells in the involved tissues scored as >50 per high-power field, with IgG4/IgG ratio >0.40.
RESULTS: According to the criteria described above 8/16 (50%) cases showed increased numbers of IgG4-positive plasma cells in the specimens. Two of these patients may have had signs of systemic disease.
CONCLUSION: Raised numbers of IgG4-positive plasma cells are a common finding in histopathological specimens of xanthogranulomatous disease of the orbit and are often not indicative for IgG4 related systemic disease.
|Number of pages||6|
|Journal||Orbit (Amsterdam, Netherlands)|
|Publication status||Published - Feb 2014|
- Aged, 80 and over
- Follow-Up Studies
- Immunoenzyme Techniques
- Immunoglobulin G/blood
- Immunosuppressive Agents/therapeutic use
- Lymphatic Diseases/blood
- Middle Aged
- Orbital Diseases/blood
- Plasma Cells/immunology
- Retrospective Studies