Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial

Yanny Y Y Cheng; Tom J T P van den Berg; Jan S Schouten; Elisabeth Pels; Robert-Jan Wijdh; Hugo van Cleynenbreugel; Catharina A Eggink; Wilhelmina J Rijneveld; Rudy M M A Nuijts

doi:10.1016/j.ajo.2011.03.012

Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial

Yanny Y Y Cheng, Tom J T P van den Berg, Jan S Schouten, Elisabeth Pels, Robert-Jan Wijdh, Hugo van Cleynenbreugel, Catharina A Eggink, Wilhelmina J Rijneveld, Rudy M M A Nuijts

Cornea

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK).

DESIGN: Prospective, randomized clinical trial.

METHODS: setting: Multicenter (5 ophthalmic centers in The Netherlands). study population: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. observation procedures: FS DSEK and PK. main outcome measures: Straylight, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score.

RESULTS: Straylight at 12 months was 1.37 ± 0.2 logarithm of straylight for FS DSEK and 1.46 ± 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P < .001) and PK (P < .001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up.

CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Straylight and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group.

Original language	English
Pages (from-to)	556-566.e1
Journal	American Journal of Ophthalmology
Volume	152
Issue number	4
DOIs	https://doi.org/10.1016/j.ajo.2011.03.012
Publication status	Published - Oct 2011

Keywords

Aged
Astigmatism/physiopathology
Cataract/complications
Cataract Extraction
Contrast Sensitivity/physiology
Corneal Diseases/complications
Descemet Stripping Endothelial Keratoplasty
Female
Follow-Up Studies
Glare
Humans
Keratoplasty, Penetrating
Laser Therapy/methods
Lens Implantation, Intraocular
Male
Prospective Studies
Quality Indicators, Health Care
Refraction, Ocular/physiology
Surveys and Questionnaires
Treatment Outcome

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10.1016/j.ajo.2011.03.012

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Cheng, Y. Y. Y., van den Berg, T. J. T. P., Schouten, J. S., Pels, E., Wijdh, R.-J., van Cleynenbreugel, H., Eggink, C. A., Rijneveld, W. J., & Nuijts, R. M. M. A. (2011). Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial. American Journal of Ophthalmology, 152(4), 556-566.e1. https://doi.org/10.1016/j.ajo.2011.03.012

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title = "Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial",

abstract = "PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK).DESIGN: Prospective, randomized clinical trial.METHODS: setting: Multicenter (5 ophthalmic centers in The Netherlands). study population: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. observation procedures: FS DSEK and PK. main outcome measures: Straylight, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score.RESULTS: Straylight at 12 months was 1.37 ± 0.2 logarithm of straylight for FS DSEK and 1.46 ± 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P < .001) and PK (P < .001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up.CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Straylight and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group.",

keywords = "Aged, Astigmatism/physiopathology, Cataract/complications, Cataract Extraction, Contrast Sensitivity/physiology, Corneal Diseases/complications, Descemet Stripping Endothelial Keratoplasty, Female, Follow-Up Studies, Glare, Humans, Keratoplasty, Penetrating, Laser Therapy/methods, Lens Implantation, Intraocular, Male, Prospective Studies, Quality Indicators, Health Care, Refraction, Ocular/physiology, Surveys and Questionnaires, Treatment Outcome",

author = "Cheng, {Yanny Y Y} and {van den Berg}, {Tom J T P} and Schouten, {Jan S} and Elisabeth Pels and Robert-Jan Wijdh and {van Cleynenbreugel}, Hugo and Eggink, {Catharina A} and Rijneveld, {Wilhelmina J} and Nuijts, {Rudy M M A}",

year = "2011",

month = oct,

doi = "10.1016/j.ajo.2011.03.012",

language = "English",

volume = "152",

pages = "556--566.e1",

number = "4",

}

Cheng, YYY, van den Berg, TJTP, Schouten, JS, Pels, E, Wijdh, R-J, van Cleynenbreugel, H, Eggink, CA, Rijneveld, WJ & Nuijts, RMMA 2011, 'Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial', American Journal of Ophthalmology, vol. 152, no. 4, pp. 556-566.e1. https://doi.org/10.1016/j.ajo.2011.03.012

Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial. / Cheng, Yanny Y Y; van den Berg, Tom J T P; Schouten, Jan S et al.
In: American Journal of Ophthalmology, Vol. 152, No. 4, 10.2011, p. 556-566.e1.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial

AU - Cheng, Yanny Y Y

AU - van den Berg, Tom J T P

AU - Schouten, Jan S

AU - Pels, Elisabeth

AU - Wijdh, Robert-Jan

AU - van Cleynenbreugel, Hugo

AU - Eggink, Catharina A

AU - Rijneveld, Wilhelmina J

AU - Nuijts, Rudy M M A

PY - 2011/10

Y1 - 2011/10

N2 - PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK).DESIGN: Prospective, randomized clinical trial.METHODS: setting: Multicenter (5 ophthalmic centers in The Netherlands). study population: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. observation procedures: FS DSEK and PK. main outcome measures: Straylight, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score.RESULTS: Straylight at 12 months was 1.37 ± 0.2 logarithm of straylight for FS DSEK and 1.46 ± 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P < .001) and PK (P < .001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up.CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Straylight and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group.

AB - PURPOSE: To compare the quality of vision (straylight and contrast sensitivity) after femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS DSEK) and penetrating keratoplasty (PK).DESIGN: Prospective, randomized clinical trial.METHODS: setting: Multicenter (5 ophthalmic centers in The Netherlands). study population: Eighty eyes of 80 patients with corneal endothelial dysfunction were included and were randomized to FS DSEK or PK. observation procedures: FS DSEK and PK. main outcome measures: Straylight, contrast sensitivity, astigmatism, uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), and visual symptom score.RESULTS: Straylight at 12 months was 1.37 ± 0.2 logarithm of straylight for FS DSEK and 1.46 ± 0.2 logarithm of straylight for PK (P = .151). During 12 months of follow-up, there was a significant improvement of straylight and contrast sensitivity after FS DSEK (P < .001) and PK (P < .001). The change of straylight and contrast sensitivity correlated significantly with the change of BSCVA after FS DSEK (r = -0.645; r = 0.580) and PK (r = -0.370; r = 0.659). The visual symptom score was comparable between the 2 groups during the 12 months of follow-up.CONCLUSIONS: Improvement of straylight and contrast sensitivity was significantly correlated with an improvement of BSCVA. Straylight and contrast sensitivity were improved significantly after FS DSEK and were comparable with those after PK, although BSCVA was slightly better in the PK group.

KW - Aged

KW - Astigmatism/physiopathology

KW - Cataract/complications

KW - Cataract Extraction

KW - Contrast Sensitivity/physiology

KW - Corneal Diseases/complications

KW - Descemet Stripping Endothelial Keratoplasty

KW - Female

KW - Follow-Up Studies

KW - Glare

KW - Humans

KW - Keratoplasty, Penetrating

KW - Laser Therapy/methods

KW - Lens Implantation, Intraocular

KW - Male

KW - Prospective Studies

KW - Quality Indicators, Health Care

KW - Refraction, Ocular/physiology

KW - Surveys and Questionnaires

KW - Treatment Outcome

U2 - 10.1016/j.ajo.2011.03.012

DO - 10.1016/j.ajo.2011.03.012

M3 - Article

C2 - 21683332

SN - 0002-9394

VL - 152

SP - 556-566.e1

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 4

ER -

Quality of vision after femtosecond laser-assisted descemet stripping endothelial keratoplasty and penetrating keratoplasty: a randomized, multicenter clinical trial

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Keywords

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