Quality of life: fractionated stereotactic radiotherapy versus enucleation treatment in uveal melanoma patients

Jackelien G M van Beek, Gabrielle H S Buitendijk, Reinier Timman, Karin Muller, Gregorius P M Luyten, Dion Paridaens, Nicole C Naus, Emine Kiliç

Research output: Contribution to journalArticleResearchpeer-review


PURPOSE: To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy (fSRT).

METHODS: Uveal melanoma (UM) patients treated with fSRT (n = 65) or enucleation (n = 48) participated in this prospective study. Questionnaires to measure anxiety (State-Trait Anxiety Inventory), subjective distress (Impact of Event Scale) and quality of life (EORTC-QLQ-C30 and National Eye Institute Visual Function Questionnaire (VFQ-25)) were obtained before treatment and 2, 6, 12, 24, 36 and 48 months after treatment.

RESULTS: Less peripheral vision was observed until 3 years (p = 0.026) posttreatment in enucleated patients compared to irradiated patients. From 2 months until 3 years posttreatment irradiated patients increase in role functioning-score (p = 0.005), while enucleated patients decrease in score (p = 0.012). Regardless of their treatment, for all patients we measured a reduction in physical functioning (p = 0.035), insomnia (p < 0.001) and in state anxiety from pretreatment until 2 years posttreatment (p < 0.001). An increase in pain overall (p = 0.023) and in emotional functioning is observed 1 year posttreatment (p < 0.001). At baseline, patients with metastases (independent of their treatment) have more subjective distress (p = 0.037) than patients without metastases. The mean 'global health score' overall, without effect of time, was 76.4 (SD: 13.6).

CONCLUSION: Enucleated patients had more difficulty working or performing household tasks 2 months posttreatment compared to irradiated patients. Enucleated patients had diminished peripheral vision until 3 years compared to irradiated patients. Overall quality of life is not significantly different between both treatment groups.

Original languageEnglish
Pages (from-to)841-848
Number of pages8
JournalActa Ophthalmologica
Issue number8
Publication statusPublished - Dec 2018


  • Adult
  • Aged
  • Aged, 80 and over
  • Eye Enucleation
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Melanoma/psychology
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Quality of Life
  • Radiosurgery/methods
  • Surveys and Questionnaires
  • Time Factors
  • Uveal Neoplasms/psychology


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