Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration

Elsbeth J T van Zeeburg; Matteo G Cereda; Sankha Amarakoon; Jan C van Meurs

doi:10.1159/000380829

Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration

Elsbeth J T van Zeeburg, Matteo G Cereda, Sankha Amarakoon, Jan C van Meurs

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: To investigate whether patients with exudative age-related macular degeneration and a submacular hemorrhage, retinal pigment epithelium (RPE) tear or nonresponders to anti-vascular endothelial growth factor (VEGF) benefit more from a free RPE-choroid graft transplantation surgery than from (continuation of) anti-VEGF treatment.

PROCEDURES: A total of 20 patients were included in this prospective, international, multicenter, randomized intervention study.

RESULTS: The change in the mean number of Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the graft group 1 year postoperatively was -15 (range -54 to +26), whilst 2 patients experienced a gain of >10 letters. The median preoperative visual acuity (VA) was 0.75 logMAR (range 0.46-2.8), and the mean postoperative VA was 1.48 logMAR (range 0.14-2.8). The change in the mean number of ETDRS letters in the anti-VEGF group was -8 (range -26 to +6); no patients experienced a >10 letter gain. The median preoperative VA was 1.36 logMAR (range 0.58-1.6), and the median postoperative VA was 1.42 logMAR (range 0.44-1.66).

CONCLUSIONS: The included patient group is far too small to draw conclusions. However, both gain and loss of VA may be experienced by patients undergoing either treatment method; more gain might be possible for patients with a graft in the absence of complications.

Original language	English
Pages (from-to)	134-45
Number of pages	12
Journal	Ophthalmologica
Volume	233
Issue number	3-4
DOIs	https://doi.org/10.1159/000380829
Publication status	Published - 2015

Keywords

Aged
Aged, 80 and over
Angiogenesis Inhibitors/therapeutic use
Choroid/transplantation
Female
Humans
Intravitreal Injections
Male
Middle Aged
Prospective Studies
Retinal Hemorrhage/therapy
Retinal Perforations/therapy
Retinal Pigment Epithelium/transplantation
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A/antagonists & inhibitors
Visual Acuity/physiology
Wet Macular Degeneration/drug therapy

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10.1159/000380829

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@article{fbf4ba06f42342989183068f68883be7,

title = "Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration",

abstract = "PURPOSE: To investigate whether patients with exudative age-related macular degeneration and a submacular hemorrhage, retinal pigment epithelium (RPE) tear or nonresponders to anti-vascular endothelial growth factor (VEGF) benefit more from a free RPE-choroid graft transplantation surgery than from (continuation of) anti-VEGF treatment.PROCEDURES: A total of 20 patients were included in this prospective, international, multicenter, randomized intervention study.RESULTS: The change in the mean number of Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the graft group 1 year postoperatively was -15 (range -54 to +26), whilst 2 patients experienced a gain of >10 letters. The median preoperative visual acuity (VA) was 0.75 logMAR (range 0.46-2.8), and the mean postoperative VA was 1.48 logMAR (range 0.14-2.8). The change in the mean number of ETDRS letters in the anti-VEGF group was -8 (range -26 to +6); no patients experienced a >10 letter gain. The median preoperative VA was 1.36 logMAR (range 0.58-1.6), and the median postoperative VA was 1.42 logMAR (range 0.44-1.66).CONCLUSIONS: The included patient group is far too small to draw conclusions. However, both gain and loss of VA may be experienced by patients undergoing either treatment method; more gain might be possible for patients with a graft in the absence of complications.",

keywords = "Aged, Aged, 80 and over, Angiogenesis Inhibitors/therapeutic use, Choroid/transplantation, Female, Humans, Intravitreal Injections, Male, Middle Aged, Prospective Studies, Retinal Hemorrhage/therapy, Retinal Perforations/therapy, Retinal Pigment Epithelium/transplantation, Tomography, Optical Coherence, Vascular Endothelial Growth Factor A/antagonists & inhibitors, Visual Acuity/physiology, Wet Macular Degeneration/drug therapy",

author = "{van Zeeburg}, {Elsbeth J T} and Cereda, {Matteo G} and Sankha Amarakoon and {van Meurs}, {Jan C}",

year = "2015",

doi = "10.1159/000380829",

language = "English",

volume = "233",

pages = "134--45",

number = "3-4",

}

Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration. / van Zeeburg, Elsbeth J T; Cereda, Matteo G; Amarakoon, Sankha et al.
In: Ophthalmologica, Vol. 233, No. 3-4, 2015, p. 134-45.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration

AU - van Zeeburg, Elsbeth J T

AU - Cereda, Matteo G

AU - Amarakoon, Sankha

AU - van Meurs, Jan C

PY - 2015

Y1 - 2015

N2 - PURPOSE: To investigate whether patients with exudative age-related macular degeneration and a submacular hemorrhage, retinal pigment epithelium (RPE) tear or nonresponders to anti-vascular endothelial growth factor (VEGF) benefit more from a free RPE-choroid graft transplantation surgery than from (continuation of) anti-VEGF treatment.PROCEDURES: A total of 20 patients were included in this prospective, international, multicenter, randomized intervention study.RESULTS: The change in the mean number of Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the graft group 1 year postoperatively was -15 (range -54 to +26), whilst 2 patients experienced a gain of >10 letters. The median preoperative visual acuity (VA) was 0.75 logMAR (range 0.46-2.8), and the mean postoperative VA was 1.48 logMAR (range 0.14-2.8). The change in the mean number of ETDRS letters in the anti-VEGF group was -8 (range -26 to +6); no patients experienced a >10 letter gain. The median preoperative VA was 1.36 logMAR (range 0.58-1.6), and the median postoperative VA was 1.42 logMAR (range 0.44-1.66).CONCLUSIONS: The included patient group is far too small to draw conclusions. However, both gain and loss of VA may be experienced by patients undergoing either treatment method; more gain might be possible for patients with a graft in the absence of complications.

AB - PURPOSE: To investigate whether patients with exudative age-related macular degeneration and a submacular hemorrhage, retinal pigment epithelium (RPE) tear or nonresponders to anti-vascular endothelial growth factor (VEGF) benefit more from a free RPE-choroid graft transplantation surgery than from (continuation of) anti-VEGF treatment.PROCEDURES: A total of 20 patients were included in this prospective, international, multicenter, randomized intervention study.RESULTS: The change in the mean number of Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the graft group 1 year postoperatively was -15 (range -54 to +26), whilst 2 patients experienced a gain of >10 letters. The median preoperative visual acuity (VA) was 0.75 logMAR (range 0.46-2.8), and the mean postoperative VA was 1.48 logMAR (range 0.14-2.8). The change in the mean number of ETDRS letters in the anti-VEGF group was -8 (range -26 to +6); no patients experienced a >10 letter gain. The median preoperative VA was 1.36 logMAR (range 0.58-1.6), and the median postoperative VA was 1.42 logMAR (range 0.44-1.66).CONCLUSIONS: The included patient group is far too small to draw conclusions. However, both gain and loss of VA may be experienced by patients undergoing either treatment method; more gain might be possible for patients with a graft in the absence of complications.

KW - Aged

KW - Aged, 80 and over

KW - Angiogenesis Inhibitors/therapeutic use

KW - Choroid/transplantation

KW - Female

KW - Humans

KW - Intravitreal Injections

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Retinal Hemorrhage/therapy

KW - Retinal Perforations/therapy

KW - Retinal Pigment Epithelium/transplantation

KW - Tomography, Optical Coherence

KW - Vascular Endothelial Growth Factor A/antagonists & inhibitors

KW - Visual Acuity/physiology

KW - Wet Macular Degeneration/drug therapy

U2 - 10.1159/000380829

DO - 10.1159/000380829

M3 - Article

C2 - 25832909

SN - 0030-3755

VL - 233

SP - 134

EP - 145

JO - Ophthalmologica

JF - Ophthalmologica

IS - 3-4

ER -

Prospective, Randomized Intervention Study Comparing Retinal Pigment Epithelium-Choroid Graft Surgery and Anti-VEGF Therapy in Patients with Exudative Age-Related Macular Degeneration

Abstract

Keywords

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