Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables

Jimena Rojas, Itziar Fernandez, Jose C Pastor, Robert E MacLaren, Yashin Ramkissoon, Steven Harsum, David G Charteris, Jan C Van Meurs, Sankha Amarakoon, Jose Garcia-Arumi, Jose M Ruiz-Moreno, Amandio Rocha-Sousa, Maria Brion, Angel Carracedo,

Research output: Contribution to journalArticleResearchpeer-review

Abstract

PURPOSE: To validate three models for predicting proliferative vitreoretinopathy (PVR) based on the analysis of genotypic data and relevant clinical characteristics.

METHODS: The validation series consisted of data from 546 patients operated on from primary rhegmatogenous retinal detachment (RRD) coming from centres in the Netherlands, Portugal, Spain and the UK. Temporal and geographical validation was performed. The discrimination capability of each model was analysed and compared with the original series, using a receiver operating curve. Then, clinical variables were combined in order to improve the predictive capability. A risk reclassification analysis was performed with and without each one of the variables. Reclassification of patients was compared and models were readjusted in the original series. Readjusted models were further validated.

RESULTS: One of the models showed good predictability in the temporal sample as well as in the original series (area under the curve (AUC) original=0.7352; AUC temporal=0.6457, 95% CI 50.17 to 78.97). When clinical variables were included, only pre-existent PVR improves the predictability of this model in the validation series (temporal and geographical samples) (AUC original=0.7940 vs AUC temporal=0.7744 and AUC geographical=0.7152). The other models showed acceptable AUC values when clinical variables were included although they were less accurate than in the original series.

CONCLUSIONS: Genetic profiling of patients with RRD can improve the predictability of PVR in addition to the well-known clinical biomarkers. This validated formula could be a new tool in our current clinical practice in order to identify those patients at high risk of developing PVR.

Original languageEnglish
Pages (from-to)41-8
Number of pages8
JournalBritish Journal of Ophthalmology
Volume99
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Adult
  • Aged
  • Area Under Curve
  • Eye Proteins/genetics
  • Female
  • Gene Expression Profiling
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • ROC Curve
  • Reproducibility of Results
  • Retinal Detachment/complications
  • Risk Assessment
  • Vitreoretinopathy, Proliferative/diagnosis

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