Abstract
HLA-B27 typing of 103 acute anterior uveitis (AAU) patients showed that 49 (48%) were positive for this antigen. Of these HLA-B27 positive AAU patients, 27 (55%) had ankylosing spondylitis (AS) according to the New York criteria. The 22 HLA-B27 positive AAU patients without AS, however, also showed symptoms and signs of AS. Seventeen (77%) of these 22 HLA-B27 positive AS negative AAU patients fulfilled a set of criteria for classification as possible AS. In the group of 54 HLA-B27 negative AAU patients, only two patients (4%) had AS. Of the remaining 52 patients only seven (13%) had possible AS. Of the 21 patients having posterior uveitis (PU) none was HLA-B27 positive nor met the criteria for AS or possible AS. These findings indicate a strong relationship between AAU, AS or possible AS and HLA-B27 and suggest that HLA-B27 typing in AAU patients is important for early diagnosis of AS.
Original language | English |
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Pages (from-to) | 137-43 |
Number of pages | 7 |
Journal | British Journal of Rheumatology |
Volume | 22 |
Issue number | 4 Suppl 2 |
DOIs | |
Publication status | Published - Nov 1983 |
Keywords
- Acute Disease
- HLA Antigens
- HLA-B27 Antigen
- Humans
- Spondylitis, Ankylosing/complications
- Uveitis, Anterior/complications