Abstract
Local application of platelet-activating factor (PAF) on the rabbit eye caused a dose-dependent significant increase in intraocular pressure (IOP). After laser irradiation of the iris the IOP showed a hypertensive phase of about 3 hr. Prophylactic treatment with the PAF antagonist BN 52021 but not with indomethacin abolished the hypertensive phase. Elevated levels of protein (10.6 +/- 0.9 g/l) and prostaglandin E2 (PGE2, 1.7 +/- 0.2 ng/ml) were measured in the aqueous humor 2 hr after laser irradiation of the iris. Prophylactic treatment with BN 52021 showed lower levels of protein (6.1 +/- 0.7) and PGE2 (1.1 +/- 0.02); with indomethacin pretreatment the level of protein was 3.4 +/- 0.7 g/l and of PGE2 0.10 +/- 0.02 ng/ml. A role of PAF as a mediator in ocular inflammatory response is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 1101-3 |
| Number of pages | 3 |
| Journal | Investigative ophthalmology & visual science |
| Volume | 30 |
| Issue number | 6 |
| Publication status | Published - Jun 1989 |
Keywords
- Animals
- Diterpenes
- Dose-Response Relationship, Drug
- Ginkgolides
- Intraocular Pressure/drug effects
- Iris/injuries
- Lactones/pharmacology
- Lasers/adverse effects
- Male
- Ocular Hypertension/etiology
- Plant Extracts/pharmacology
- Platelet Activating Factor/antagonists & inhibitors
- Rabbits
- Radiation Injuries, Experimental/prevention & control