Platelet-activating factor and laser trauma of the iris

N L Verbey, J L Van Delft, N J Van Haeringen, P Braquet

    Research output: Contribution to journalArticleResearchpeer-review


    Local application of platelet-activating factor (PAF) on the rabbit eye caused a dose-dependent significant increase in intraocular pressure (IOP). After laser irradiation of the iris the IOP showed a hypertensive phase of about 3 hr. Prophylactic treatment with the PAF antagonist BN 52021 but not with indomethacin abolished the hypertensive phase. Elevated levels of protein (10.6 +/- 0.9 g/l) and prostaglandin E2 (PGE2, 1.7 +/- 0.2 ng/ml) were measured in the aqueous humor 2 hr after laser irradiation of the iris. Prophylactic treatment with BN 52021 showed lower levels of protein (6.1 +/- 0.7) and PGE2 (1.1 +/- 0.02); with indomethacin pretreatment the level of protein was 3.4 +/- 0.7 g/l and of PGE2 0.10 +/- 0.02 ng/ml. A role of PAF as a mediator in ocular inflammatory response is suggested.

    Original languageEnglish
    Pages (from-to)1101-3
    Number of pages3
    JournalInvestigative ophthalmology & visual science
    Issue number6
    Publication statusPublished - Jun 1989


    • Animals
    • Diterpenes
    • Dose-Response Relationship, Drug
    • Ginkgolides
    • Intraocular Pressure/drug effects
    • Iris/injuries
    • Lactones/pharmacology
    • Lasers/adverse effects
    • Male
    • Ocular Hypertension/etiology
    • Plant Extracts/pharmacology
    • Platelet Activating Factor/antagonists & inhibitors
    • Rabbits
    • Radiation Injuries, Experimental/prevention & control


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