Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review

M Veckeneer; L Derycke; E W Lindstedt; J van Meurs; M Cornelissen; M Bracke; E Van Aken

doi:10.1007/s00417-011-1870-y

Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review

M Veckeneer, L Derycke, E W Lindstedt, J van Meurs, M Cornelissen, M Bracke, E Van Aken

Vitreoretinal surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: Persistent subretinal fluid after rhegmatogenous retinal detachment (RRD) surgery is responsible for delayed recovery, and may affect the final visual outcome. Cause, consequences, and treatment remain elusive.

DESIGN: Literature review and case series.

METHODS: We reviewed the pathophysiological principles and therapeutic options from the literature, and we report the results from a subretinal fluid cytology study. Nine eyes from nine patients with macula-involving RRD underwent surgical repair. The cellular content of subretinal fluid (SRF) was studied by electron microscopy and anti-rhodopsin immunostaining. All eyes were assessed postoperatively with optical coherence tomography for the detection of persistent submacular fluid (PSF) (Ethics Committee Ghent University Hospital, registration number B6702006169).

RESULTS: Certain patient characteristics as well as surgical methods were implicated. PSF appears to occur more frequently in patients with longstanding detachments treated with buckling surgery. Several therapeutic options have been suggested but safety and efficacy remain unclear. We found PSF in three eyes on postoperative OCT scans, which corresponded to the three cell-rich subretinal samples.

CONCLUSIONS: PSF after successful RRD repair seems to be related to fluid composition. We hypothesize, in the absence of an effective treatment, that a modified surgical drainage, including a washout of the subretinal space, could evacuate the subretinal fluid more completely, and may prevent this complication.

Original language	English
Pages (from-to)	795-802
Number of pages	8
Journal	Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
Volume	250
Issue number	6
DOIs	https://doi.org/10.1007/s00417-011-1870-y
Publication status	Published - Jun 2012

Keywords

Aged
Aged, 80 and over
Drainage
Female
Humans
Immunohistochemistry
Male
Microscopy, Electron, Transmission
Middle Aged
Postoperative Complications
Retinal Detachment/physiopathology
Rhodopsin/metabolism
Rod Cell Outer Segment/metabolism
Scleral Buckling
Subretinal Fluid/cytology
Tomography, Optical Coherence
Visual Acuity/physiology
Vitrectomy

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10.1007/s00417-011-1870-y

Cite this

Veckeneer, M., Derycke, L., Lindstedt, E. W., van Meurs, J., Cornelissen, M., Bracke, M., & Van Aken, E. (2012). Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 250(6), 795-802. https://doi.org/10.1007/s00417-011-1870-y

@article{c16f7e36770c40a8b5fce4ea92a247fb,

title = "Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review",

abstract = "BACKGROUND: Persistent subretinal fluid after rhegmatogenous retinal detachment (RRD) surgery is responsible for delayed recovery, and may affect the final visual outcome. Cause, consequences, and treatment remain elusive.DESIGN: Literature review and case series.METHODS: We reviewed the pathophysiological principles and therapeutic options from the literature, and we report the results from a subretinal fluid cytology study. Nine eyes from nine patients with macula-involving RRD underwent surgical repair. The cellular content of subretinal fluid (SRF) was studied by electron microscopy and anti-rhodopsin immunostaining. All eyes were assessed postoperatively with optical coherence tomography for the detection of persistent submacular fluid (PSF) (Ethics Committee Ghent University Hospital, registration number B6702006169).RESULTS: Certain patient characteristics as well as surgical methods were implicated. PSF appears to occur more frequently in patients with longstanding detachments treated with buckling surgery. Several therapeutic options have been suggested but safety and efficacy remain unclear. We found PSF in three eyes on postoperative OCT scans, which corresponded to the three cell-rich subretinal samples.CONCLUSIONS: PSF after successful RRD repair seems to be related to fluid composition. We hypothesize, in the absence of an effective treatment, that a modified surgical drainage, including a washout of the subretinal space, could evacuate the subretinal fluid more completely, and may prevent this complication.",

keywords = "Aged, Aged, 80 and over, Drainage, Female, Humans, Immunohistochemistry, Male, Microscopy, Electron, Transmission, Middle Aged, Postoperative Complications, Retinal Detachment/physiopathology, Rhodopsin/metabolism, Rod Cell Outer Segment/metabolism, Scleral Buckling, Subretinal Fluid/cytology, Tomography, Optical Coherence, Visual Acuity/physiology, Vitrectomy",

author = "M Veckeneer and L Derycke and Lindstedt, {E W} and {van Meurs}, J and M Cornelissen and M Bracke and {Van Aken}, E",

year = "2012",

month = jun,

doi = "10.1007/s00417-011-1870-y",

language = "English",

volume = "250",

pages = "795--802",

number = "6",

}

Veckeneer, M, Derycke, L, Lindstedt, EW, van Meurs, J, Cornelissen, M, Bracke, M & Van Aken, E 2012, 'Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review', Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, vol. 250, no. 6, pp. 795-802. https://doi.org/10.1007/s00417-011-1870-y

Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review. / Veckeneer, M; Derycke, L; Lindstedt, E W et al.
In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Vol. 250, No. 6, 06.2012, p. 795-802.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment

T2 - hypothesis and review

AU - Veckeneer, M

AU - Derycke, L

AU - Lindstedt, E W

AU - van Meurs, J

AU - Cornelissen, M

AU - Bracke, M

AU - Van Aken, E

PY - 2012/6

Y1 - 2012/6

N2 - BACKGROUND: Persistent subretinal fluid after rhegmatogenous retinal detachment (RRD) surgery is responsible for delayed recovery, and may affect the final visual outcome. Cause, consequences, and treatment remain elusive.DESIGN: Literature review and case series.METHODS: We reviewed the pathophysiological principles and therapeutic options from the literature, and we report the results from a subretinal fluid cytology study. Nine eyes from nine patients with macula-involving RRD underwent surgical repair. The cellular content of subretinal fluid (SRF) was studied by electron microscopy and anti-rhodopsin immunostaining. All eyes were assessed postoperatively with optical coherence tomography for the detection of persistent submacular fluid (PSF) (Ethics Committee Ghent University Hospital, registration number B6702006169).RESULTS: Certain patient characteristics as well as surgical methods were implicated. PSF appears to occur more frequently in patients with longstanding detachments treated with buckling surgery. Several therapeutic options have been suggested but safety and efficacy remain unclear. We found PSF in three eyes on postoperative OCT scans, which corresponded to the three cell-rich subretinal samples.CONCLUSIONS: PSF after successful RRD repair seems to be related to fluid composition. We hypothesize, in the absence of an effective treatment, that a modified surgical drainage, including a washout of the subretinal space, could evacuate the subretinal fluid more completely, and may prevent this complication.

AB - BACKGROUND: Persistent subretinal fluid after rhegmatogenous retinal detachment (RRD) surgery is responsible for delayed recovery, and may affect the final visual outcome. Cause, consequences, and treatment remain elusive.DESIGN: Literature review and case series.METHODS: We reviewed the pathophysiological principles and therapeutic options from the literature, and we report the results from a subretinal fluid cytology study. Nine eyes from nine patients with macula-involving RRD underwent surgical repair. The cellular content of subretinal fluid (SRF) was studied by electron microscopy and anti-rhodopsin immunostaining. All eyes were assessed postoperatively with optical coherence tomography for the detection of persistent submacular fluid (PSF) (Ethics Committee Ghent University Hospital, registration number B6702006169).RESULTS: Certain patient characteristics as well as surgical methods were implicated. PSF appears to occur more frequently in patients with longstanding detachments treated with buckling surgery. Several therapeutic options have been suggested but safety and efficacy remain unclear. We found PSF in three eyes on postoperative OCT scans, which corresponded to the three cell-rich subretinal samples.CONCLUSIONS: PSF after successful RRD repair seems to be related to fluid composition. We hypothesize, in the absence of an effective treatment, that a modified surgical drainage, including a washout of the subretinal space, could evacuate the subretinal fluid more completely, and may prevent this complication.

KW - Aged

KW - Aged, 80 and over

KW - Drainage

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Microscopy, Electron, Transmission

KW - Middle Aged

KW - Postoperative Complications

KW - Retinal Detachment/physiopathology

KW - Rhodopsin/metabolism

KW - Rod Cell Outer Segment/metabolism

KW - Scleral Buckling

KW - Subretinal Fluid/cytology

KW - Tomography, Optical Coherence

KW - Visual Acuity/physiology

KW - Vitrectomy

U2 - 10.1007/s00417-011-1870-y

DO - 10.1007/s00417-011-1870-y

M3 - Review article

C2 - 22234351

SN - 0065-6100

VL - 250

SP - 795

EP - 802

JO - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

IS - 6

ER -

Veckeneer M, Derycke L, Lindstedt EW, van Meurs J, Cornelissen M, Bracke M et al. Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2012 Jun;250(6):795-802. doi: 10.1007/s00417-011-1870-y

Persistent subretinal fluid after surgery for rhegmatogenous retinal detachment: hypothesis and review

Abstract

Keywords

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