Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases

M Sotodeh, D Paridaens, J Keunen, M van Schooneveld, G Adamus, S Baarsma

Research output: Contribution to journalArticleProfessionalpeer-review


PURPOSE: To report unusual vitelliform fundus findings in three cases of paraneoplastic retinopathy associated with metastasised cutaneous or uveal melanoma and in one case, a unique immunoreactivity response.

PATIENTS AND METHODS: Observational case series. The histories of three patients with MAR-like paraneoplastic retinopathy were reviewed. Electroretinography, Goldmann perimetry, fluorescein angiography, and in one case optical coherence tomography, immunohistochemistry and Western blotting were performed.

RESULTS: All patients revealed similar paraneoplastic vitelliform retinal abnormalities. Symptoms in two cases differed from the classical MAR syndrome. In one case, western blotting and immunohistochemistry demonstrated antibodies against 120-kDa, a soluble photoreceptor protein. No immunoreactivity to retinal bipolar cells was detected.

CONCLUSION: The clinical, electrophysiological, and immunological findings in our patients suggest a melanoma associated paraneoplastic origin, like in MAR syndrome. However contrary to MAR syndrome, this paraneoplastic vitelliform retinopathy exhibits a peculiar fundus picture, consisting of serous macular detachment and nummular vitelliform lesions in the posterior pole. This could be an unusual presentation of MAR or a separate paraneoplastic entity.

Original languageEnglish
Pages (from-to)910-4
Number of pages5
JournalKlinische Monatsblatter fur Augenheilkunde
Issue number11
Publication statusPublished - Nov 2005


  • Female
  • Humans
  • Male
  • Melanoma/pathology
  • Middle Aged
  • Paraneoplastic Syndromes/pathology
  • Retinal Degeneration/pathology
  • Skin Neoplasms/pathology
  • Uveal Neoplasms/pathology


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