Orbital chondrosarcoma developing in a patient with Paget disease

C M Mooy, N C Naus, A de Klein, W A van den Bosch, D A Paridaens

Research output: Contribution to journalLetterpeer-review

Abstract

PURPOSE: To describe the radiologic, histopathologic, and cytogenetic features of an orbital chondrosarcoma developing in a patient with Paget disease.

METHODS: A 64-year-old woman presented with rapidly progressive proptosis of her right eye. Computed tomographic scans, histopathologic examination, and cytogenetic analysis were performed.

RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease. A soft-tissue tumor in the right lateral orbital wall was consistent with Paget sarcoma. On histology, a chondrosarcoma was diagnosed, which was confirmed by fluorescent in situ hybridization.

CONCLUSION: This is a unique case of orbital chondrosarcoma developing in a patient with Paget disease.

Original languageEnglish
Pages (from-to)619-21
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume127
Issue number5
DOIs
Publication statusPublished - May 1999

Keywords

  • Chondrosarcoma/diagnostic imaging
  • DNA, Neoplasm/analysis
  • Female
  • Frontal Bone/pathology
  • Humans
  • In Situ Hybridization, Fluorescence
  • Middle Aged
  • Orbital Neoplasms/diagnostic imaging
  • Osteitis Deformans/complications
  • Temporal Bone/pathology
  • Tomography, X-Ray Computed

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