Abstract
PurposeThe purpose of this study is to investigate the reperfusion of translocated retinal pigment epithelium (RPE)-choroid graft in the treatment of patients with neovascular age-related macular degeneration (nAMD), using OCT angiography (OCTA), a novel non-invasive, high-resolution imaging modality.Patients and methodsEighteen eyes of 18 consecutive patients suffering from complicated nAMD underwent RPE-choroid patch graft translocation surgery using a peripheral retinotomy and flap-over technique. We analyzed functional and anatomical outcome using visual acuity, Spectral Domain OCT and OCTA.ResultsWith a mean follow-up of 11 months, out of 18 patients, 15 gained vision, 1 remained stable, and 2 lost vision. Overall, the visual acuity improved with a mean of 30 letters. Perfusion of the graft tissue was confirmed in all patients. Two patients developed signs of a recurrent neovascular membrane during follow-up. No cases of proliferative vitreoretinopathy occurred in this series.ConclusionsOCTA images show signs of perfusion in all grafts. Encouraging functional results and low risk of severe complications suggest that RPE-choroid graft translocation is a valid option in patients with complicated nAMD.
Original language | English |
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Pages (from-to) | 1274-1283 |
Number of pages | 10 |
Journal | Eye (London, England) |
Volume | 31 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 2017 |
Keywords
- Aged
- Aged, 80 and over
- Choroid/physiopathology
- Ciliary Arteries/physiology
- Computed Tomography Angiography
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Reperfusion
- Retinal Pigment Epithelium/physiopathology
- Retrospective Studies
- Surgical Flaps
- Tomography, Optical Coherence
- Transplantation, Autologous
- Visual Acuity/physiology
- Visual Field Tests
- Wet Macular Degeneration/physiopathology