PURPOSE: To increase insight into the myopic presentation of central serous chorioretinopathy (CSC) by comparing a large group of myopic patients with CSC to reference groups with only one of the diagnoses.
METHODS: Myopic cases with CSC (spherical equivalent (SE) ≤-3D, n=46), emmetropic patients with CSC (SE -0.5 to 0.5D, n=83) and myopic, non CSC, patients (n=50) were included in this multicentre cross-sectional study. Disease characteristics and imaging parameters, like subfoveal choroidal thickness (SFCT) and ICGA patterns, were compared between cases and reference groups.
RESULTS: In myopic CSC cases, median SFCT (286 μm (IQR 226-372μm) was significantly thicker than SFCT in myopic, non CSC patients (200 μm (IQR 152-228μm), p<0.001), but thinner than emmetropic CSC patients (452 μm (IQR 342-538 μm), p<0.001). They also had pachyvessels in 70% of the eyes, comparable to emmetropic CSC (76%, p=0.70). Choroidal hyperpermeability was frequently present on ICGA in both myopic and emmetropic CSC eyes. Need for treatment, treatment success or recurrence rate were not significantly different between CSC groups.
CONCLUSION: Myopic CSC presents with similar imaging and clinical characteristics as emmetropic CSC, apart from their thinner choroids. Keeping in mind the structural changes of myopia, other imaging characteristics could aid the diagnostic process.