TY - JOUR
T1 - Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology
AU - Springelkamp, Henriët
AU - Mishra, Aniket
AU - Hysi, Pirro G
AU - Gharahkhani, Puya
AU - Höhn, René
AU - Khor, Chiea-Chuen
AU - Cooke Bailey, Jessica N
AU - Luo, Xiaoyan
AU - Ramdas, Wishal D
AU - Vithana, Eranga
AU - Koh, Victor
AU - Yazar, Seyhan
AU - Xu, Liang
AU - Forward, Hannah
AU - Kearns, Lisa S
AU - Amin, Najaf
AU - Iglesias, Adriana I
AU - Sim, Kar-Seng
AU - van Leeuwen, Elisabeth M
AU - Demirkan, Ayse
AU - van der Lee, Sven
AU - Loon, Seng-Chee
AU - Rivadeneira, Fernando
AU - Nag, Abhishek
AU - Sanfilippo, Paul G
AU - Schillert, Arne
AU - de Jong, Paulus T V M
AU - Oostra, Ben A
AU - Uitterlinden, André G
AU - Hofman, Albert
AU - Zhou, Tiger
AU - Burdon, Kathryn P
AU - Spector, Timothy D
AU - Lackner, Karl J
AU - Saw, Seang-Mei
AU - Vingerling, Johannes R
AU - Teo, Yik-Ying
AU - Pasquale, Louis R
AU - Wolfs, Roger C W
AU - Lemij, Hans G
AU - Tai, E-Shyong
AU - Jonas, Jost B
AU - Cheng, Ching-Yu
AU - Aung, Tin
AU - Jansonius, Nomdo M
AU - Klaver, Caroline C W
AU - Craig, Jamie E
AU - Young, Terri L
AU - Haines, Jonathan L
AU - MacGregor, Stuart
AU - Mackey, David A
AU - Pfeiffer, Norbert
AU - Wong, Tien-Yin
AU - Wiggs, Janey L
AU - Hewitt, Alex W
AU - Duijn, Cornelia M van
AU - Hammond, Christopher J
N1 - © 2015 Wiley Periodicals, Inc.
PY - 2015/3
Y1 - 2015/3
N2 - Primary open-angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in two parts: a central cup (without nerve fibers) surrounded by the neuroretinal rim (containing axons of the retinal ganglion cells). The International Glaucoma Genetics Consortium conducted a meta-analysis of genome-wide association studies consisting of 17,248 individuals of European ancestry and 6,841 individuals of Asian ancestry. The outcomes of the genome-wide association studies were disc area and cup area. These specific measurements describe optic nerve morphology in another way than the vertical cup-disc ratio, which is a clinically used measurement, and may shed light on new glaucoma mechanisms. We identified 10 new loci associated with disc area (CDC42BPA, F5, DIRC3, RARB, ABI3BP, DCAF4L2, ELP4, TMTC2, NR2F2, and HORMAD2) and another 10 new loci associated with cup area (DHRS3, TRIB2, EFEMP1, FLNB, FAM101, DDHD1, ASB7, KPNB1, BCAS3, and TRIOBP). The new genes participate in a number of pathways and future work is likely to identify more functions related to the pathogenesis of glaucoma.
AB - Primary open-angle glaucoma is the most common optic neuropathy and an important cause of irreversible blindness worldwide. The optic nerve head or optic disc is divided in two parts: a central cup (without nerve fibers) surrounded by the neuroretinal rim (containing axons of the retinal ganglion cells). The International Glaucoma Genetics Consortium conducted a meta-analysis of genome-wide association studies consisting of 17,248 individuals of European ancestry and 6,841 individuals of Asian ancestry. The outcomes of the genome-wide association studies were disc area and cup area. These specific measurements describe optic nerve morphology in another way than the vertical cup-disc ratio, which is a clinically used measurement, and may shed light on new glaucoma mechanisms. We identified 10 new loci associated with disc area (CDC42BPA, F5, DIRC3, RARB, ABI3BP, DCAF4L2, ELP4, TMTC2, NR2F2, and HORMAD2) and another 10 new loci associated with cup area (DHRS3, TRIB2, EFEMP1, FLNB, FAM101, DDHD1, ASB7, KPNB1, BCAS3, and TRIOBP). The new genes participate in a number of pathways and future work is likely to identify more functions related to the pathogenesis of glaucoma.
KW - Asian Continental Ancestry Group/genetics
KW - European Continental Ancestry Group/genetics
KW - Genome-Wide Association Study
KW - Glaucoma/ethnology
KW - Humans
KW - Optic Disk/pathology
KW - Optic Nerve Diseases/ethnology
KW - Quantitative Trait Loci/genetics
U2 - 10.1002/gepi.21886
DO - 10.1002/gepi.21886
M3 - Article
C2 - 25631615
SN - 0741-0395
VL - 39
SP - 207
EP - 216
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - 3
ER -