Malignant pleural mesothelioma with lacrimal gland metastasis

Hanida Hanafi, Rob M Verdijk, Dion Paridaens

Research output: Contribution to journalLetterpeer-review


PURPOSE: To describe a rare clinical case of biopsy-proven metastatic mesothelioma of the lacrimal gland which responded well to chemo and radiation therapy.

METHODS: Interventional case report.

RESULTS: A 55-year-old woman with an untreated malignant biopsy-proven pleural mesothelioma presented with right proptosis, diplopia and hypoglobus. Magnetic resonance imaging showed an aggressive lacrimal gland tumour with bony erosion. A biopsy concluded a diagnosis of metastatic mesothelioma of the lacrimal gland. Her lacrimal and lung tumours showed a marked regression following palliative chemo (carboplatin) and radiation therapy.

CONCLUSIONS: Malignant pleural mesothelioma may metastasize to the orbit, including the lacrimal gland. A combined chemo and radiation therapy may reduce the size of the metastatic and primary tumour.

Original languageEnglish
Pages (from-to)836-838
Number of pages3
JournalActa Ophthalmologica
Issue number8
Publication statusPublished - Dec 2016


  • Biopsy
  • Carboplatin/therapeutic use
  • Chemoradiotherapy
  • Eye Neoplasms/diagnostic imaging
  • Female
  • Humans
  • Lacrimal Apparatus Diseases/diagnostic imaging
  • Lung Neoplasms/diagnostic imaging
  • Magnetic Resonance Imaging
  • Mesothelioma/diagnostic imaging
  • Middle Aged
  • Pleural Neoplasms/pathology


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