Low level IGF-1 and common variable immune deficiency: an unusual combination

K van Bilsen; G J Driessen; R A de Paus; E van de Vosse; K van Lom; M C van Zelm; K H Lam; N G Hartwig; G S Baarsma; M van de Burg; P M van Hagen

Low level IGF-1 and common variable immune deficiency: an unusual combination

K van Bilsen, G J Driessen, R A de Paus, E van de Vosse, K van Lom, M C van Zelm, K H Lam, N G Hartwig, G S Baarsma, M van de Burg, P M van Hagen

Medical retina and Uveitis

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Abstract

A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways.

Original language	English
Pages (from-to)	368-72
Number of pages	5
Journal	The Netherlands journal of medicine
Volume	66
Issue number	9
Publication status	Published - Oct 2008

Keywords

Adolescent
Antibodies, Anti-Idiotypic/blood
Biomarkers/blood
Common Variable Immunodeficiency/blood
Follow-Up Studies
Humans
Immunoglobulin A/blood
Immunoglobulin G/blood
Insulin-Like Growth Factor I/deficiency
Male
Time Factors

Cite this

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title = "Low level IGF-1 and common variable immune deficiency: an unusual combination",

abstract = "A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways.",

keywords = "Adolescent, Antibodies, Anti-Idiotypic/blood, Biomarkers/blood, Common Variable Immunodeficiency/blood, Follow-Up Studies, Humans, Immunoglobulin A/blood, Immunoglobulin G/blood, Insulin-Like Growth Factor I/deficiency, Male, Time Factors",

author = "{van Bilsen}, K and Driessen, {G J} and {de Paus}, {R A} and {van de Vosse}, E and {van Lom}, K and {van Zelm}, {M C} and Lam, {K H} and Hartwig, {N G} and Baarsma, {G S} and {van de Burg}, M and {van Hagen}, {P M}",

year = "2008",

month = oct,

language = "English",

volume = "66",

pages = "368--72",

number = "9",

}

TY - JOUR

T1 - Low level IGF-1 and common variable immune deficiency

T2 - an unusual combination

AU - van Bilsen, K

AU - Driessen, G J

AU - de Paus, R A

AU - van de Vosse, E

AU - van Lom, K

AU - van Zelm, M C

AU - Lam, K H

AU - Hartwig, N G

AU - Baarsma, G S

AU - van de Burg, M

AU - van Hagen, P M

PY - 2008/10

Y1 - 2008/10

N2 - A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways.

AB - A relation between growth hormone (GH) deficiency and immunoglobulin deficiency has been suggested previously in a few cases. We describe a patient with an insulin-like growth factor 1 (IGF-1) deficiency and common variable immune deficiency and briefly review earlier publications on the possible interaction between IGF-1 and the immune system. IGF-1 is the downstream mediator of GH. In this patient, GH and IGF-1 levels were both low. The GH response to a GH-releasing hormone test was normal whereas no subsequent IGF-1 response was seen. In our cohort of 14 patients with hypogammaglobulinaemia, two turned out to have slightly decreased IGF-1 serum levels and one patient with a thymoma had an increased IGF-1 level. Even though IGF-1 may be connected to B lymphocyte differentiation, in this patient we hypothesise there is a common impairment in the IGF-1 and IgG pathways.

KW - Adolescent

KW - Antibodies, Anti-Idiotypic/blood

KW - Biomarkers/blood

KW - Common Variable Immunodeficiency/blood

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin A/blood

KW - Immunoglobulin G/blood

KW - Insulin-Like Growth Factor I/deficiency

KW - Male

KW - Time Factors

M3 - Article

C2 - 18931397

SN - 0300-2977

VL - 66

SP - 368

EP - 372

JO - The Netherlands journal of medicine

JF - The Netherlands journal of medicine

IS - 9

ER -

Low level IGF-1 and common variable immune deficiency: an unusual combination

Abstract

Keywords

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