Long overall survival after dendritic cell vaccination in metastatic uveal melanoma patients

Kalijn F Bol, Hanneke W Mensink, Erik H J G Aarntzen, Gerty Schreibelt, Jan E E Keunen, Pierre G Coulie, Annelies de Klein, Cornelis J A Punt, Dion Paridaens, Carl G Figdor, I Jolanda M de Vries

Research output: Contribution to journalArticleResearchpeer-review

Abstract

PURPOSE: To assess the safety and efficacy of dendritic cell vaccination in metastatic uveal melanoma.

DESIGN: Interventional case series.

METHODS: We analyzed 14 patients with metastatic uveal melanoma treated with dendritic cell vaccination. Patients with metastatic uveal melanoma received at least 3 vaccinations with autologous dendritic cells, professional antigen-presenting cells loaded with melanoma antigens gp100 and tyrosinase. The main outcome measures were safety, immunologic response, and overall survival.

RESULTS: Tumor-specific immune responses were induced with dendritic cell vaccination in 4 (29%) of 14 patients. Dendritic cell-vaccinated patients showed a median overall survival with metastatic disease of 19.2 months, relatively long compared with that reported in the literature. No severe treatment-related toxicities (common toxicity criteria grade 3 or 4) were observed.

CONCLUSIONS: Dendritic cell vaccination is feasible and safe in metastatic uveal melanoma. Dendritic cell-based immunotherapy is potent to enhance the host's antitumor immunity against uveal melanoma in approximately one third of patients. Compared with other prospective studies with similar inclusion criteria, dendritic cell vaccination may be associated with longer than average overall survival in patients with metastatic uveal melanoma.

Original languageEnglish
Pages (from-to)939-47
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume158
Issue number5
DOIs
Publication statusPublished - Nov 2014

Keywords

  • Cancer Vaccines/therapeutic use
  • Dendritic Cells/immunology
  • Follow-Up Studies
  • Humans
  • Melanoma/mortality
  • Neoplasm Metastasis
  • Netherlands/epidemiology
  • Prospective Studies
  • Survival Rate/trends
  • Time Factors
  • Uveal Neoplasms/mortality
  • Vaccination/methods
  • gp100 Melanoma Antigen/immunology

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