Infectious crystalline keratopathy

Lies Remeijer, Gabriel van Rij, Cornelia M Mooij, Willem Houdijn Beekhuis, J C G Renardel de Lavalette

    Research output: Contribution to journalArticleResearchpeer-review


    In seven patients white branched crystalline opacities, which grew very slowly, were seen in the corneal stroma. They were associated with very little inflammatory activity, so that the clinical picture at first did not suggest an infectious etiology. Pathological examination, however, demonstrated colonies of bacteria between intact corneal lamellae. On bacterial examination gram-positive commensals were mainly found.
    All the patients described so far were found to be taking corticosteroids regularly, sometimes in combination with antibiotics. The immunosuppression brought about by corticosteroids is probably an important factor in the development of these crystalline opacities.
    The therapy for this infectious crystalline keratopathy is difficult and lengthy. It consists of local bactericidal antibiotics and the lowest possible dosage of corticosteroids, if necessary combined with a partial lamellar keratectomy and removal of the affected corneal tissue by fraising.
    Original languageEnglish
    Pages (from-to)95-103
    Number of pages9
    JournalDocumenta Ophthalmologica
    Publication statusPublished - Sept 1987


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