TY - JOUR
T1 - Immuunstromale corneale ulceratie na een oogoperatie bij patiënten met collageen-vasculaire auto-immuunaandoeningen
AU - van der Meulen, I J E
AU - van Rooij, J
AU - Hazes, J W M
AU - van Cleynenbreugel, H
AU - Geerards, A J M
AU - Remeijer, Lies
PY - 2007/4/21
Y1 - 2007/4/21
N2 - Two women aged 78 and 74 years respectively, both with dry eyes due to underlying auto-immune disorders, presented after uncomplicated cataract surgery with immunostromal corneal ulceration. Intensive topical lubrication combined with systemic immunosuppressants were necessary to control the corneal melt. Dry eyes are a frequently-encountered problem among patients with rheumatoid disorders and increase the risk of corneal melting. Auto-immune related corneal melting can occur spontaneously or after ocular surgery, it threatens visual acuity and ocular integrity and may be associated with systemic vasculitis. When treating patients with rheumatoid disorders, the presence of dry eyes and the accompanying risk of serious complications need to be ascertained. In patients at risk, pre-operative preventive measures to suppress any underlying systemic disorders and improve the ocular environment are necessary. When corneal melting is diagnosed, aggressive topical therapy combined with systemic immunosuppressants is indicated.
AB - Two women aged 78 and 74 years respectively, both with dry eyes due to underlying auto-immune disorders, presented after uncomplicated cataract surgery with immunostromal corneal ulceration. Intensive topical lubrication combined with systemic immunosuppressants were necessary to control the corneal melt. Dry eyes are a frequently-encountered problem among patients with rheumatoid disorders and increase the risk of corneal melting. Auto-immune related corneal melting can occur spontaneously or after ocular surgery, it threatens visual acuity and ocular integrity and may be associated with systemic vasculitis. When treating patients with rheumatoid disorders, the presence of dry eyes and the accompanying risk of serious complications need to be ascertained. In patients at risk, pre-operative preventive measures to suppress any underlying systemic disorders and improve the ocular environment are necessary. When corneal melting is diagnosed, aggressive topical therapy combined with systemic immunosuppressants is indicated.
KW - Administration, Topical
KW - Aged
KW - Autoimmune Diseases/complications
KW - Cataract Extraction/adverse effects
KW - Corneal Diseases/drug therapy
KW - Corneal Ulcer/etiology
KW - Dry Eye Syndromes/complications
KW - Female
KW - Humans
KW - Immunosuppressive Agents/therapeutic use
KW - Ophthalmic Solutions/administration & dosage
KW - Postoperative Complications
KW - Treatment Outcome
KW - Visual Acuity
M3 - Brief
C2 - 17500345
SN - 0028-2162
VL - 151
SP - 920
EP - 923
JO - Nederlands Tijdschrift voor Geneeskunde
JF - Nederlands Tijdschrift voor Geneeskunde
IS - 16
ER -