Hyalocytes in proliferative vitreo-retinal diseases

Charlotte H Jones, Wei Gui, Ricarda G Schumann, Stefaniya K Boneva, Clemens AK Lange, Koen A van Overdam, Toco YP Chui, Richard B Rosen, Michael Engelbert, J Sebag

Research output: Contribution to journalReview articlepeer-review


Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases.
Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes.
Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.
Original languageEnglish
Pages (from-to)263-280
Number of pages18
JournalExpert Review of Ophthalmology
Issue number4
Publication statusPublished - 4 Jul 2022


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