Human herpes simplex virus keratitis: the pathogenesis revisited

Lies Remeijer, Albert Osterhaus, Georges M G M Verjans

Research output: Contribution to journalReview articlepeer-review


Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.

Original languageEnglish
Pages (from-to)255-85
Number of pages31
JournalOcular Immunology and Inflammation
Issue number4
Publication statusPublished - Dec 2004


  • Herpesvirus 1, Human/pathogenicity
  • Humans
  • Keratitis, Herpetic/etiology
  • T-Lymphocytes/immunology


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