Abstract
Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.
Original language | English |
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Pages (from-to) | 255-85 |
Number of pages | 31 |
Journal | Ocular Immunology and Inflammation |
Volume | 12 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2004 |
Keywords
- Herpesvirus 1, Human/pathogenicity
- Humans
- Keratitis, Herpetic/etiology
- T-Lymphocytes/immunology