Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma

Robert M Verdijk, Thomas van den Bosch, Nicole C Naus, Dion Paridaens, Cornelia M Mooy, Annelies de Klein

Research output: Contribution to journalLetterResearchpeer-review

Abstract

The histological findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms. Oncocytic change is defined histologically by abundant, eosinophilic, finely granular cytoplasm due to densely packed mitochondria. Oncocytic change has rarely been described in dermal nevi, meningeal melanocytoma, cutaneous melanoma, or metastatic melanoma. To our knowledge, we give the first description of exclusively oncocytic uveal melanoma.
Original languageEnglish
Pages (from-to)1501-2
Number of pages2
JournalJAMA Ophthalmology
Volume129
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Aged
  • Biomarkers, Tumor/analysis
  • Cytogenetic Analysis
  • Eye Enucleation
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Melanoma/genetics
  • Neoplasm Proteins/analysis
  • Oxyphil Cells/pathology
  • Polymorphism, Single Nucleotide
  • Uveal Neoplasms/genetics
  • Visual Acuity

Fingerprint

Dive into the research topics of 'Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma'. Together they form a unique fingerprint.

Cite this