Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma

Robert M Verdijk; Thomas van den Bosch; Nicole C Naus; Dion Paridaens; Cornelia M Mooy; Annelies de Klein

doi:10.1001/archophthalmol.2011.312

Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma

Robert M Verdijk, Thomas van den Bosch, Nicole C Naus, Dion Paridaens, Cornelia M Mooy, Annelies de Klein

Research output: Contribution to journal › Letter › peer-review

Abstract

The histological findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms. Oncocytic change is defined histologically by abundant, eosinophilic, finely granular cytoplasm due to densely packed mitochondria. Oncocytic change has rarely been described in dermal nevi, meningeal melanocytoma, cutaneous melanoma, or metastatic melanoma. To our knowledge, we give the first description of exclusively oncocytic uveal melanoma.

Original language	English
Pages (from-to)	1501-2
Number of pages	2
Journal	JAMA Ophthalmology
Volume	129
Issue number	11
DOIs	https://doi.org/10.1001/archophthalmol.2011.312
Publication status	Published - Nov 2011

Keywords

Aged
Biomarkers, Tumor/analysis
Cytogenetic Analysis
Eye Enucleation
Humans
In Situ Hybridization, Fluorescence
Male
Melanoma/genetics
Neoplasm Proteins/analysis
Oxyphil Cells/pathology
Polymorphism, Single Nucleotide
Uveal Neoplasms/genetics
Visual Acuity

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10.1001/archophthalmol.2011.312

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title = "Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma",

abstract = "The histological findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms. Oncocytic change is defined histologically by abundant, eosinophilic, finely granular cytoplasm due to densely packed mitochondria. Oncocytic change has rarely been described in dermal nevi, meningeal melanocytoma, cutaneous melanoma, or metastatic melanoma. To our knowledge, we give the first description of exclusively oncocytic uveal melanoma.",

keywords = "Aged, Biomarkers, Tumor/analysis, Cytogenetic Analysis, Eye Enucleation, Humans, In Situ Hybridization, Fluorescence, Male, Melanoma/genetics, Neoplasm Proteins/analysis, Oxyphil Cells/pathology, Polymorphism, Single Nucleotide, Uveal Neoplasms/genetics, Visual Acuity",

author = "Verdijk, {Robert M} and {van den Bosch}, Thomas and Naus, {Nicole C} and Dion Paridaens and Mooy, {Cornelia M} and {de Klein}, Annelies",

year = "2011",

month = nov,

doi = "10.1001/archophthalmol.2011.312",

language = "English",

volume = "129",

pages = "1501--2",

number = "11",

}

TY - JOUR

T1 - Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma

AU - Verdijk, Robert M

AU - van den Bosch, Thomas

AU - Naus, Nicole C

AU - Paridaens, Dion

AU - Mooy, Cornelia M

AU - de Klein, Annelies

PY - 2011/11

Y1 - 2011/11

N2 - The histological findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms. Oncocytic change is defined histologically by abundant, eosinophilic, finely granular cytoplasm due to densely packed mitochondria. Oncocytic change has rarely been described in dermal nevi, meningeal melanocytoma, cutaneous melanoma, or metastatic melanoma. To our knowledge, we give the first description of exclusively oncocytic uveal melanoma.

AB - The histological findings of malignant melanoma may be highly variable, and the tumor can mimic many other neoplasms. Oncocytic change is defined histologically by abundant, eosinophilic, finely granular cytoplasm due to densely packed mitochondria. Oncocytic change has rarely been described in dermal nevi, meningeal melanocytoma, cutaneous melanoma, or metastatic melanoma. To our knowledge, we give the first description of exclusively oncocytic uveal melanoma.

KW - Aged

KW - Biomarkers, Tumor/analysis

KW - Cytogenetic Analysis

KW - Eye Enucleation

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Melanoma/genetics

KW - Neoplasm Proteins/analysis

KW - Oxyphil Cells/pathology

KW - Polymorphism, Single Nucleotide

KW - Uveal Neoplasms/genetics

KW - Visual Acuity

U2 - 10.1001/archophthalmol.2011.312

DO - 10.1001/archophthalmol.2011.312

M3 - Letter

C2 - 22084225

SN - 2168-6165

VL - 129

SP - 1501

EP - 1502

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

IS - 11

ER -

Histopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis of oncocytic uveal melanoma

Abstract

Keywords

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