Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1

J Maertzdorf; A Van der Lelij; G S Baarsma; A D Osterhaus; G M Verjans

doi:10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y

Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1

J Maertzdorf, A Van der Lelij, G S Baarsma, A D Osterhaus, G M Verjans

Medical retina and Uveitis

Research output: Contribution to journal › Letter › peer-review

Abstract

Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients.

Original language	English
Pages (from-to)	104-6
Number of pages	3
Journal	Annals of Neurology
Volume	49
Issue number	1
DOIs	https://doi.org/10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y
Publication status	Published - Jan 2001

Keywords

Aged
Base Sequence
DNA, Viral/genetics
Encephalitis, Herpes Simplex/genetics
Female
Herpesvirus 1, Human/genetics
Humans
Male
Middle Aged
Molecular Sequence Data
Retinitis/genetics

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10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y

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@article{98fe6fc75b674335b10d2749cdbfcd9a,

title = "Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1",

abstract = "Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients.",

keywords = "Aged, Base Sequence, DNA, Viral/genetics, Encephalitis, Herpes Simplex/genetics, Female, Herpesvirus 1, Human/genetics, Humans, Male, Middle Aged, Molecular Sequence Data, Retinitis/genetics",

author = "J Maertzdorf and {Van der Lelij}, A and Baarsma, {G S} and Osterhaus, {A D} and Verjans, {G M}",

year = "2001",

month = jan,

doi = "10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y",

language = "English",

volume = "49",

pages = "104--6",

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TY - JOUR

T1 - Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis

T2 - indications for brain-to-eye transmission of HSV-1

AU - Maertzdorf, J

AU - Van der Lelij, A

AU - Baarsma, G S

AU - Osterhaus, A D

AU - Verjans, G M

PY - 2001/1

Y1 - 2001/1

N2 - Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients.

AB - Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients.

KW - Aged

KW - Base Sequence

KW - DNA, Viral/genetics

KW - Encephalitis, Herpes Simplex/genetics

KW - Female

KW - Herpesvirus 1, Human/genetics

KW - Humans

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Retinitis/genetics

U2 - 10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y

DO - 10.1002/1531-8249(200101)49:1<104::aid-ana15>3.0.co;2-y

M3 - Letter

C2 - 11198277

SN - 0364-5134

VL - 49

SP - 104

EP - 106

JO - Annals of Neurology

JF - Annals of Neurology

IS - 1

ER -

Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1

Abstract

Keywords

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