Herpes simplex virus 1 transmission through corneal transplantation

L Remeijer, J Maertzdorf, P Doornenbal, G M Verjans, A D Osterhaus

Research output: Contribution to journalLetterpeer-review


Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.

Original languageEnglish
Pages (from-to)442
JournalLancet (London, England)
Issue number9254
Publication statusPublished - 10 Feb 2001


  • Adult
  • Antibodies, Viral/blood
  • DNA Fingerprinting
  • Glaucoma/congenital
  • Herpesvirus 1, Human/genetics
  • Humans
  • Keratitis, Herpetic/immunology
  • Keratoplasty, Penetrating
  • Male
  • Polymerase Chain Reaction
  • Reoperation
  • Tissue Donors
  • Virus Activation


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