Herpes simplex virus 1 transmission through corneal transplantation

L Remeijer; J Maertzdorf; P Doornenbal; G M Verjans; A D Osterhaus

doi:10.1016/S0140-6736(00)04011-3

Herpes simplex virus 1 transmission through corneal transplantation

L Remeijer, J Maertzdorf, P Doornenbal, G M Verjans, A D Osterhaus

Cornea

Research output: Contribution to journal › Letter › peer-review

Abstract

Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.

Original language	English
Pages (from-to)	442
Journal	Lancet (London, England)
Volume	357
Issue number	9254
DOIs	https://doi.org/10.1016/S0140-6736(00)04011-3
Publication status	Published - 10 Feb 2001

Keywords

Adult
Antibodies, Viral/blood
DNA Fingerprinting
Glaucoma/congenital
Herpesvirus 1, Human/genetics
Humans
Keratitis, Herpetic/immunology
Keratoplasty, Penetrating
Male
Polymerase Chain Reaction
Reoperation
Tissue Donors
Virus Activation

Access to Document

10.1016/S0140-6736(00)04011-3

Cite this

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title = "Herpes simplex virus 1 transmission through corneal transplantation",

abstract = "Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.",

keywords = "Adult, Antibodies, Viral/blood, DNA Fingerprinting, Glaucoma/congenital, Herpesvirus 1, Human/genetics, Humans, Keratitis, Herpetic/immunology, Keratoplasty, Penetrating, Male, Polymerase Chain Reaction, Reoperation, Tissue Donors, Virus Activation",

author = "L Remeijer and J Maertzdorf and P Doornenbal and Verjans, {G M} and Osterhaus, {A D}",

year = "2001",

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doi = "10.1016/S0140-6736(00)04011-3",

language = "English",

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TY - JOUR

T1 - Herpes simplex virus 1 transmission through corneal transplantation

AU - Remeijer, L

AU - Maertzdorf, J

AU - Doornenbal, P

AU - Verjans, G M

AU - Osterhaus, A D

PY - 2001/2/10

Y1 - 2001/2/10

N2 - Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.

AB - Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.

KW - Adult

KW - Antibodies, Viral/blood

KW - DNA Fingerprinting

KW - Glaucoma/congenital

KW - Herpesvirus 1, Human/genetics

KW - Humans

KW - Keratitis, Herpetic/immunology

KW - Keratoplasty, Penetrating

KW - Male

KW - Polymerase Chain Reaction

KW - Reoperation

KW - Tissue Donors

KW - Virus Activation

U2 - 10.1016/S0140-6736(00)04011-3

DO - 10.1016/S0140-6736(00)04011-3

M3 - Letter

C2 - 11273067

SN - 0140-6736

VL - 357

SP - 442

JO - Lancet (London, England)

JF - Lancet (London, England)

IS - 9254

ER -