Eyelid Merkel cell carcinoma in a patient treated with golimumab

H Hanafi; R M Verdijk; D Paridaens

doi:10.1080/01676830.2017.1353118

Eyelid Merkel cell carcinoma in a patient treated with golimumab

H Hanafi, R M Verdijk, D Paridaens

Orbita and oculoplastic surgery

Research output: Contribution to journal › Letter › peer-review

Abstract

PURPOSE: To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).

METHODS: Interventional case report.

RESULTS: A 73-year-old woman with a history of chronic RA presented with a right upper eyelid mass. She had been treated with golimumab (tumor necrosis factor (TNF) inhibitors) injection therapy for the past 6 months. A biopsy showed findings suggestive of a Merkel cell carcinoma of the eyelid.

CONCLUSIONS: Merkel cell carcinoma may be associated with anti-TNF treatment and should be included in the differential diagnosis of an eyelid tumor in patients treated with TNF inhibitors.

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Orbit (Amsterdam, Netherlands)
Volume	37
Issue number	1
DOIs	https://doi.org/10.1080/01676830.2017.1353118
Publication status	Published - Feb 2018

Keywords

Aged
Antibodies, Monoclonal/adverse effects
Arthritis, Rheumatoid/drug therapy
Carcinoma, Merkel Cell/chemically induced
Chronic Disease
Combined Modality Therapy
Dose Fractionation, Radiation
Eyelid Neoplasms/chemically induced
Female
Humans
Immunosuppressive Agents/adverse effects
Ophthalmologic Surgical Procedures
Radiotherapy Dosage
Reconstructive Surgical Procedures
Tumor Necrosis Factor-alpha/antagonists & inhibitors

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10.1080/01676830.2017.1353118

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title = "Eyelid Merkel cell carcinoma in a patient treated with golimumab",

abstract = "PURPOSE: To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).METHODS: Interventional case report.RESULTS: A 73-year-old woman with a history of chronic RA presented with a right upper eyelid mass. She had been treated with golimumab (tumor necrosis factor (TNF) inhibitors) injection therapy for the past 6 months. A biopsy showed findings suggestive of a Merkel cell carcinoma of the eyelid.CONCLUSIONS: Merkel cell carcinoma may be associated with anti-TNF treatment and should be included in the differential diagnosis of an eyelid tumor in patients treated with TNF inhibitors.",

keywords = "Aged, Antibodies, Monoclonal/adverse effects, Arthritis, Rheumatoid/drug therapy, Carcinoma, Merkel Cell/chemically induced, Chronic Disease, Combined Modality Therapy, Dose Fractionation, Radiation, Eyelid Neoplasms/chemically induced, Female, Humans, Immunosuppressive Agents/adverse effects, Ophthalmologic Surgical Procedures, Radiotherapy Dosage, Reconstructive Surgical Procedures, Tumor Necrosis Factor-alpha/antagonists & inhibitors",

author = "H Hanafi and Verdijk, {R M} and D Paridaens",

year = "2018",

month = feb,

doi = "10.1080/01676830.2017.1353118",

language = "English",

volume = "37",

pages = "21--25",

number = "1",

}

TY - JOUR

T1 - Eyelid Merkel cell carcinoma in a patient treated with golimumab

AU - Hanafi, H

AU - Verdijk, R M

AU - Paridaens, D

PY - 2018/2

Y1 - 2018/2

N2 - PURPOSE: To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).METHODS: Interventional case report.RESULTS: A 73-year-old woman with a history of chronic RA presented with a right upper eyelid mass. She had been treated with golimumab (tumor necrosis factor (TNF) inhibitors) injection therapy for the past 6 months. A biopsy showed findings suggestive of a Merkel cell carcinoma of the eyelid.CONCLUSIONS: Merkel cell carcinoma may be associated with anti-TNF treatment and should be included in the differential diagnosis of an eyelid tumor in patients treated with TNF inhibitors.

AB - PURPOSE: To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).METHODS: Interventional case report.RESULTS: A 73-year-old woman with a history of chronic RA presented with a right upper eyelid mass. She had been treated with golimumab (tumor necrosis factor (TNF) inhibitors) injection therapy for the past 6 months. A biopsy showed findings suggestive of a Merkel cell carcinoma of the eyelid.CONCLUSIONS: Merkel cell carcinoma may be associated with anti-TNF treatment and should be included in the differential diagnosis of an eyelid tumor in patients treated with TNF inhibitors.

KW - Aged

KW - Antibodies, Monoclonal/adverse effects

KW - Arthritis, Rheumatoid/drug therapy

KW - Carcinoma, Merkel Cell/chemically induced

KW - Chronic Disease

KW - Combined Modality Therapy

KW - Dose Fractionation, Radiation

KW - Eyelid Neoplasms/chemically induced

KW - Female

KW - Humans

KW - Immunosuppressive Agents/adverse effects

KW - Ophthalmologic Surgical Procedures

KW - Radiotherapy Dosage

KW - Reconstructive Surgical Procedures

KW - Tumor Necrosis Factor-alpha/antagonists & inhibitors

U2 - 10.1080/01676830.2017.1353118

DO - 10.1080/01676830.2017.1353118

M3 - Letter

C2 - 28841334

SN - 0167-6830

VL - 37

SP - 21

EP - 25

JO - Orbit (Amsterdam, Netherlands)

JF - Orbit (Amsterdam, Netherlands)

IS - 1

ER -

Eyelid Merkel cell carcinoma in a patient treated with golimumab

Abstract

Keywords

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