Eyelid Merkel cell carcinoma in a patient treated with golimumab

H Hanafi, R M Verdijk, D Paridaens

Research output: Contribution to journalLetterpeer-review


PURPOSE: To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).

METHODS: Interventional case report.

RESULTS: A 73-year-old woman with a history of chronic RA presented with a right upper eyelid mass. She had been treated with golimumab (tumor necrosis factor (TNF) inhibitors) injection therapy for the past 6 months. A biopsy showed findings suggestive of a Merkel cell carcinoma of the eyelid.

CONCLUSIONS: Merkel cell carcinoma may be associated with anti-TNF treatment and should be included in the differential diagnosis of an eyelid tumor in patients treated with TNF inhibitors.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalOrbit (Amsterdam, Netherlands)
Issue number1
Publication statusPublished - Feb 2018


  • Aged
  • Antibodies, Monoclonal/adverse effects
  • Arthritis, Rheumatoid/drug therapy
  • Carcinoma, Merkel Cell/chemically induced
  • Chronic Disease
  • Combined Modality Therapy
  • Dose Fractionation, Radiation
  • Eyelid Neoplasms/chemically induced
  • Female
  • Humans
  • Immunosuppressive Agents/adverse effects
  • Ophthalmologic Surgical Procedures
  • Radiotherapy Dosage
  • Reconstructive Surgical Procedures
  • Tumor Necrosis Factor-alpha/antagonists & inhibitors


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