Endothelial cell density after posterior lamellar keratoplasty: five- to seven-year follow-up

Bart T H van Dooren; Paul G H Mulder; Carla P Nieuwendaal; W Houdijn Beekhuis; Gerrit R J Melles

doi:10.1016/j.ajo.2007.05.015

Endothelial cell density after posterior lamellar keratoplasty: five- to seven-year follow-up

Bart T H van Dooren, Paul G H Mulder, Carla P Nieuwendaal, W Houdijn Beekhuis, Gerrit R J Melles

Research output: Contribution to journal › Article › Research › peer-review

Abstract

PURPOSE: To report endothelial cell density (ECD) after posterior lamellar keratoplasty (PLK).

DESIGN: Prospective, interventional case series.

METHODS: In a single institution, PLK was performed in 15 eyes of 15 patients with pseudophakic bullous keratopathy (PPBK), Fuchs endothelial dystrophy (FED), or both. In 11 eyes, the donor tissue was inserted unfolded through a 9.0-mm sclerocorneal incision. In four eyes, the donor was folded and inserted through a 5.0-mm incision. The ECD measurements were performed in each patient at regular intervals until three years after surgery, and then in all patients simultaneously at 54 to 84 months after surgery.

RESULTS: Three patients were not available for follow-up. One graft had decompensated. In the remaining 11 eyes, ECDs ranged from 368 to 1576 cells/mm(2). Monophasic and biphasic regression models of ECD against time were fitted for each technique separately.

CONCLUSIONS: After PLK, ECD declined at a high rate. Both early- and longer-term loss rates may be related to surgical technique.

Original language	English
Pages (from-to)	471-3
Number of pages	3
Journal	American Journal of Ophthalmology
Volume	144
Issue number	3
DOIs	https://doi.org/10.1016/j.ajo.2007.05.015
Publication status	Published - Sept 2007

Keywords

Aged
Aged, 80 and over
Cell Count
Corneal Diseases/surgery
Corneal Transplantation
Endothelium, Corneal/pathology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Postoperative Complications
Prospective Studies

Access to Document

10.1016/j.ajo.2007.05.015

Cite this

@article{1d3c020acaab4848bbfdaa6f6972074a,

title = "Endothelial cell density after posterior lamellar keratoplasty: five- to seven-year follow-up",

abstract = "PURPOSE: To report endothelial cell density (ECD) after posterior lamellar keratoplasty (PLK).DESIGN: Prospective, interventional case series.METHODS: In a single institution, PLK was performed in 15 eyes of 15 patients with pseudophakic bullous keratopathy (PPBK), Fuchs endothelial dystrophy (FED), or both. In 11 eyes, the donor tissue was inserted unfolded through a 9.0-mm sclerocorneal incision. In four eyes, the donor was folded and inserted through a 5.0-mm incision. The ECD measurements were performed in each patient at regular intervals until three years after surgery, and then in all patients simultaneously at 54 to 84 months after surgery.RESULTS: Three patients were not available for follow-up. One graft had decompensated. In the remaining 11 eyes, ECDs ranged from 368 to 1576 cells/mm(2). Monophasic and biphasic regression models of ECD against time were fitted for each technique separately.CONCLUSIONS: After PLK, ECD declined at a high rate. Both early- and longer-term loss rates may be related to surgical technique.",

keywords = "Aged, Aged, 80 and over, Cell Count, Corneal Diseases/surgery, Corneal Transplantation, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications, Prospective Studies",

author = "{van Dooren}, {Bart T H} and Mulder, {Paul G H} and Nieuwendaal, {Carla P} and Beekhuis, {W Houdijn} and Melles, {Gerrit R J}",

year = "2007",

month = sep,

doi = "10.1016/j.ajo.2007.05.015",

language = "English",

volume = "144",

pages = "471--3",

number = "3",

}

TY - JOUR

T1 - Endothelial cell density after posterior lamellar keratoplasty

T2 - five- to seven-year follow-up

AU - van Dooren, Bart T H

AU - Mulder, Paul G H

AU - Nieuwendaal, Carla P

AU - Beekhuis, W Houdijn

AU - Melles, Gerrit R J

PY - 2007/9

Y1 - 2007/9

N2 - PURPOSE: To report endothelial cell density (ECD) after posterior lamellar keratoplasty (PLK).DESIGN: Prospective, interventional case series.METHODS: In a single institution, PLK was performed in 15 eyes of 15 patients with pseudophakic bullous keratopathy (PPBK), Fuchs endothelial dystrophy (FED), or both. In 11 eyes, the donor tissue was inserted unfolded through a 9.0-mm sclerocorneal incision. In four eyes, the donor was folded and inserted through a 5.0-mm incision. The ECD measurements were performed in each patient at regular intervals until three years after surgery, and then in all patients simultaneously at 54 to 84 months after surgery.RESULTS: Three patients were not available for follow-up. One graft had decompensated. In the remaining 11 eyes, ECDs ranged from 368 to 1576 cells/mm(2). Monophasic and biphasic regression models of ECD against time were fitted for each technique separately.CONCLUSIONS: After PLK, ECD declined at a high rate. Both early- and longer-term loss rates may be related to surgical technique.

AB - PURPOSE: To report endothelial cell density (ECD) after posterior lamellar keratoplasty (PLK).DESIGN: Prospective, interventional case series.METHODS: In a single institution, PLK was performed in 15 eyes of 15 patients with pseudophakic bullous keratopathy (PPBK), Fuchs endothelial dystrophy (FED), or both. In 11 eyes, the donor tissue was inserted unfolded through a 9.0-mm sclerocorneal incision. In four eyes, the donor was folded and inserted through a 5.0-mm incision. The ECD measurements were performed in each patient at regular intervals until three years after surgery, and then in all patients simultaneously at 54 to 84 months after surgery.RESULTS: Three patients were not available for follow-up. One graft had decompensated. In the remaining 11 eyes, ECDs ranged from 368 to 1576 cells/mm(2). Monophasic and biphasic regression models of ECD against time were fitted for each technique separately.CONCLUSIONS: After PLK, ECD declined at a high rate. Both early- and longer-term loss rates may be related to surgical technique.

KW - Aged

KW - Aged, 80 and over

KW - Cell Count

KW - Corneal Diseases/surgery

KW - Corneal Transplantation

KW - Endothelium, Corneal/pathology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Prospective Studies

U2 - 10.1016/j.ajo.2007.05.015

DO - 10.1016/j.ajo.2007.05.015

M3 - Article

C2 - 17765439

SN - 0002-9394

VL - 144

SP - 471

EP - 473

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 3

ER -

Endothelial cell density after posterior lamellar keratoplasty: five- to seven-year follow-up

Abstract

Keywords

Access to Document

Fingerprint

Cite this