TY - JOUR
T1 - Differences in clinical presentation of primary open-angle glaucoma between African and European populations
AU - Bonnemaijer, Pieter W M
AU - Lo Faro, Valeria
AU - Sanyiwa, Anna J
AU - Hassan, Hassan G
AU - Cook, Colin
AU - Van de Laar, Suzanne
AU - Lemij, Hans G
AU - Klaver, Caroline C W
AU - Jansonius, Nomdo M
AU - Thiadens, Alberta A H J
N1 - © 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.
PY - 2021/11
Y1 - 2021/11
N2 - Purpose: Primary open-angle glaucoma (POAG) has been reported to occur more frequently in Africans, and to follow a more severe course compared to Europeans. We aimed to describe characteristics of POAG presentation and treatment across three ethnic groups from Africa and one from Europe. Methods: We ascertained 151 POAG patients from South African Coloured (SAC) and 94 South African Black (SAB) ethnicity from a university hospital in South Africa. In Tanzania, 310 patients were recruited from a university hospital and a referral hospital. In the Netherlands, 241 patients of European ancestry were included. All patients were over 35 years old and had undergone an extensive ophthalmic examination. Patients were diagnosed according to the ISGEO criteria. A biogeographic ancestry analysis was performed to estimate the proportion of genetic African ancestry (GAA). Results: The biogeographic ancestry analysis showed that the median proportion of GAA was 97.6% in Tanzanian, 100% in SAB, 34.2% in SAC and 1.5% in Dutch participants. Clinical characteristics at presentation for Tanzanians, SAB, SAC and Dutch participants, respectively: mean age: 63, 57, 66, 70 years (p
AB - Purpose: Primary open-angle glaucoma (POAG) has been reported to occur more frequently in Africans, and to follow a more severe course compared to Europeans. We aimed to describe characteristics of POAG presentation and treatment across three ethnic groups from Africa and one from Europe. Methods: We ascertained 151 POAG patients from South African Coloured (SAC) and 94 South African Black (SAB) ethnicity from a university hospital in South Africa. In Tanzania, 310 patients were recruited from a university hospital and a referral hospital. In the Netherlands, 241 patients of European ancestry were included. All patients were over 35 years old and had undergone an extensive ophthalmic examination. Patients were diagnosed according to the ISGEO criteria. A biogeographic ancestry analysis was performed to estimate the proportion of genetic African ancestry (GAA). Results: The biogeographic ancestry analysis showed that the median proportion of GAA was 97.6% in Tanzanian, 100% in SAB, 34.2% in SAC and 1.5% in Dutch participants. Clinical characteristics at presentation for Tanzanians, SAB, SAC and Dutch participants, respectively: mean age: 63, 57, 66, 70 years (p
KW - Africa
KW - Europe
KW - South Africa
KW - Tanzania
KW - glaucoma
KW - primary open-angle glaucoma
UR - https://www.mendeley.com/catalogue/f1273078-1c1f-3470-a070-d0eb48b1c1ce/
U2 - 10.1111/aos.14772
DO - 10.1111/aos.14772
M3 - Article
C2 - 33555657
SN - 1755-375X
VL - 99
SP - e1118-e1126
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 7
ER -