Dexamethasone in ophthalmology: Pharmacokinetics after various routes of administration

Olga Weijtens

    Research output: Types of ThesisDoctoral Thesis

    Abstract

    The aim of this thesis was to gain more knowledge of the pharmacokinetics of coricosteroids after various commonly used administration routes in humans. We chose to use dexamethasone disodium phosphate for our studies because this preparation is widely used for topical application in the Netherlands, whereas its ocular penetration has not yet been studied in humans. Moreover, with a water-soluble, short acting preparation, the pharmacokinetics after subconjunctival and peribulbar injections could be more accurately studied than with a lipid-soluble depot preparation.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    Supervisors/Advisors
    • Cohen, Adam F, Supervisor
    • van Meurs, Jan, Supervisor
    Publication statusPublished - 2002

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