Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation

W H Beekhuis, Marjolijn Bartels, Ilias I N Doxiadis, Gabriel van Rij

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable.

    METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate').

    RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty.

    CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.

    Original languageEnglish
    Title of host publicationDevelopments in Ophthalmology
    Subtitle of host publicationAdequate HLA Matching in Keratoplasty
    EditorsR Sundmacher
    Number of pages10
    ISBN (Electronic)978-3-318-00905-7
    Publication statusPublished - 2002

    Publication series

    NameDevelopments in Ophthalmology
    PublisherS Karger AG
    ISSN (Print)0250-3751


    • Adolescent
    • Adult
    • Aged
    • Aged, 80 and over
    • Child
    • Cornea/immunology
    • Female
    • Graft Survival/physiology
    • HLA-A Antigens/immunology
    • HLA-B Antigens/immunology
    • Histocompatibility/physiology
    • Histocompatibility Testing
    • Humans
    • Keratoplasty, Penetrating/immunology
    • Male
    • Middle Aged
    • Retrospective Studies
    • Tissue Donors


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