Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation

W H Beekhuis; Marjolijn Bartels; Ilias I N Doxiadis; Gabriel van Rij

doi:10.1159/isbn.978-3-318-00905-7

Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation

W H Beekhuis, Marjolijn Bartels, Ilias I N Doxiadis, Gabriel van Rij

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable.

METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate').

RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty.

CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.

Original language	English
Title of host publication	Developments in Ophthalmology
Subtitle of host publication	Adequate HLA Matching in Keratoplasty
Editors	R Sundmacher
Pages	12-21
Number of pages	10
Volume	36
ISBN (Electronic)	978-3-318-00905-7
DOIs	https://doi.org/10.1159/isbn.978-3-318-00905-7
Publication status	Published - 2002

Publication series

Name	Developments in Ophthalmology
Publisher	S Karger AG
ISSN (Print)	0250-3751

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Child
Cornea/immunology
Female
Graft Survival/physiology
HLA-A Antigens/immunology
HLA-B Antigens/immunology
Histocompatibility/physiology
Histocompatibility Testing
Humans
Keratoplasty, Penetrating/immunology
Male
Middle Aged
Retrospective Studies
Tissue Donors

Access to Document

10.1159/isbn.978-3-318-00905-7

Cite this

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title = "Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation",

abstract = "BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable.METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate').RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty.CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Cornea/immunology, Female, Graft Survival/physiology, HLA-A Antigens/immunology, HLA-B Antigens/immunology, Histocompatibility/physiology, Histocompatibility Testing, Humans, Keratoplasty, Penetrating/immunology, Male, Middle Aged, Retrospective Studies, Tissue Donors",

author = "Beekhuis, {W H} and Marjolijn Bartels and Doxiadis, {Ilias I N} and {van Rij}, Gabriel",

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doi = "10.1159/isbn.978-3-318-00905-7",

language = "English",

isbn = "978-3-8055-7487-7",

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Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation. / Beekhuis, W H; Bartels, Marjolijn; Doxiadis, Ilias I N et al.
Developments in Ophthalmology: Adequate HLA Matching in Keratoplasty. ed. / R Sundmacher. Vol. 36 2002. p. 12-21 (Developments in Ophthalmology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation

AU - Beekhuis, W H

AU - Bartels, Marjolijn

AU - Doxiadis, Ilias I N

AU - van Rij, Gabriel

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N2 - BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable.METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate').RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty.CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.

AB - BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable.METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate').RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty.CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.

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KW - Histocompatibility Testing

KW - Humans

KW - Keratoplasty, Penetrating/immunology

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Tissue Donors

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A2 - Sundmacher, R

ER -

Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation

Abstract

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Keywords

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